Analysis Tools|
Allele Symbol Allele Name Allele ID |
Cd8b1+ wild type MGI:2430275 |
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| Summary |
3 genotypes
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• in peripheral blood
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• in peripheral blood
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• in peripheral blood
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• in peripheral blood
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• CD8 to CD4 ratio is 2.2-fold lower than in wild-type
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• there is a lack of mature CD8-lineage T cells
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• mice have 3-fold fewer CD8-lineage thymocytes compared to wild-type
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• thymocytes display 4-fold less CD8-associated Lck activity vs wild-type
• activity of Lck is reduced but significant levels are detected in mutants; there is a slight reduction in CD8a-associated activity compared to wild-type
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• CD8 to CD4 ratio is 2.2-fold lower than in wild-type
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• there is a lack of mature CD8-lineage T cells
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• mice have 3-fold fewer CD8-lineage thymocytes compared to wild-type
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• mice have 3-fold fewer CD8-lineage thymocytes compared to wild-type
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• male transgenic mice show disruption of relative and absolute numbers of double positive T cells in the thymus
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• male transgenic mice show disruption of relative and absolute numbers of double positive T cells in the thymus
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 12/30/2025 MGI 6.24 |
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