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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Cd14+
wild type
MGI:2430251
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
ht1
 		Cd14tm1Frm/Cd14+ involves: 129S4/SvJae * C57BL/6J MGI:3583157


Genotype
MGI:3583157
ht1
Allelic
Composition		 Cd14tm1Frm/Cd14+
Genetic
Background		 involves: 129S4/SvJae * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cd14tm1Frm mutation (2 available); any Cd14 mutation (21 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
abnormal cytokine secretion ( J:65107 )
• macrophages exhibited a decrease in cytokine production in response to LPS
decreased interleukin-6 secretion ( J:65107 )
• decreased IL-6 production by macrophages in response to LPS
decreased tumor necrosis factor secretion ( J:65107 )
• decreased TNF production by macrophages in response to LPS




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
03/18/2025
MGI 6.24 		The Jackson Laboratory