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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Bcl2l1+
wild type
MGI:2430059
Summary 6 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
ht1
 		Bcl2l1tm1Dlo/Bcl2l1+ B6.Cg-Bcl2l1tm1Dlo MGI:3847902
ht2
 		Bcl2l1Plt16/Bcl2l1+ involves: BALB/c * C57BL/6 MGI:3847898
ht3
 		Bcl2l1Plt20/Bcl2l1+ involves: BALB/c * C57BL/6 MGI:3847901
cx4
 		Bak1tm1Thsn/Bak1+
Bcl2l1tm1Dlo/Bcl2l1+ 		B6.Cg-Bcl2l1tm1Dlo Bak1tm1Thsn MGI:3847904
cx5
 		Bak1tm1Thsn/Bak1tm1Thsn
Bcl2l1tm1Dlo/Bcl2l1+ 		B6.Cg-Bcl2l1tm1Dlo Bak1tm1Thsn MGI:3847907
cx6
 		Bak1tm1Thsn/Bak1+
Bcl2l1Plt20/Bcl2l1+ 		involves: 129 * BALB/c * C57BL/6 MGI:3847906


Genotype
MGI:3847902
ht1
Allelic
Composition		 Bcl2l1tm1Dlo/Bcl2l1+
Genetic
Background		 B6.Cg-Bcl2l1tm1Dlo
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Bcl2l1tm1Dlo mutation (0 available); any Bcl2l1 mutation (110 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system
thrombocytopenia ( J:149205 )
• platelet counts are significantly lower than controls (860x103/microliter vs 1100x103/microliter)
abnormal platelet physiology ( J:149205 )
• platelet half-life is significantly reduced compared to controls (57 hours to 30 hours)

homeostasis/metabolism
abnormal platelet physiology ( J:149205 )
• platelet half-life is significantly reduced compared to controls (57 hours to 30 hours)




Genotype
MGI:3847898
ht2
Allelic
Composition		 Bcl2l1Plt16/Bcl2l1+
Genetic
Background		 involves: BALB/c * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Bcl2l1Plt16 mutation (0 available); any Bcl2l1 mutation (110 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system
increased megakaryocyte cell number ( J:149205 )
• megakaryocyte numbers are marginally elevated compared to controls
thrombocytopenia ( J:149205 )
• platelet counts are significantly lower than controls (596x103/microliter vs 1100x103/microliter)
abnormal platelet physiology ( J:149205 )
• platelet half-life is significantly reduced compared to controls (57 hours to 30 hours)

homeostasis/metabolism
abnormal platelet physiology ( J:149205 )
• platelet half-life is significantly reduced compared to controls (57 hours to 30 hours)




Genotype
MGI:3847901
ht3
Allelic
Composition		 Bcl2l1Plt20/Bcl2l1+
Genetic
Background		 involves: BALB/c * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Bcl2l1Plt20 mutation (1 available); any Bcl2l1 mutation (110 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system
increased megakaryocyte cell number ( J:149205 )
• megakaryocyte numbers are marginally elevated compared to controls
thrombocytopenia ( J:149205 )
• platelet counts are significantly lower than controls (598x103/microliter vs 1100x103/microliter)
abnormal platelet physiology ( J:149205 )
• platelet half-life is reduced by 50% compared to controls (57 hours to 24 hours)

homeostasis/metabolism
abnormal platelet physiology ( J:149205 )
• platelet half-life is reduced by 50% compared to controls (57 hours to 24 hours)




Genotype
MGI:3847904
cx4
Allelic
Composition		 Bak1tm1Thsn/Bak1+
Bcl2l1tm1Dlo/Bcl2l1+
Genetic
Background		 B6.Cg-Bcl2l1tm1Dlo Bak1tm1Thsn
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Bak1tm1Thsn mutation (2 available); any Bak1 mutation (26 available)
Bcl2l1tm1Dlo mutation (0 available); any Bcl2l1 mutation (110 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system
abnormal platelet morphology ( J:149205 )
• the low platelet numbers of Bcl2l1tm1Dlo heterozygotes do not occur in these mice




Genotype
MGI:3847907
cx5
Allelic
Composition		 Bak1tm1Thsn/Bak1tm1Thsn
Bcl2l1tm1Dlo/Bcl2l1+
Genetic
Background		 B6.Cg-Bcl2l1tm1Dlo Bak1tm1Thsn
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Bak1tm1Thsn mutation (2 available); any Bak1 mutation (26 available)
Bcl2l1tm1Dlo mutation (0 available); any Bcl2l1 mutation (110 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system
thrombocytosis ( J:149205 )
• platelet cell numbers are about 50% higher than controls
abnormal platelet physiology ( J:149205 )
• platelet half-life is significantly increased by about 50% compared to controls

homeostasis/metabolism
abnormal platelet physiology ( J:149205 )
• platelet half-life is significantly increased by about 50% compared to controls




Genotype
MGI:3847906
cx6
Allelic
Composition		 Bak1tm1Thsn/Bak1+
Bcl2l1Plt20/Bcl2l1+
Genetic
Background		 involves: 129 * BALB/c * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Bak1tm1Thsn mutation (2 available); any Bak1 mutation (26 available)
Bcl2l1Plt20 mutation (1 available); any Bcl2l1 mutation (110 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system
abnormal platelet morphology ( J:149205 )
• the low platelet numbers of Bcl2l1Plt20 heterozygotes do not occur in these mice




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
01/20/2026
MGI 6.24 		The Jackson Laboratory