Phenotypes associated with this allele

• Allele Symbol: Wdfy3⁺
• Allele Name: wild type
• Allele ID: MGI:2430025
• Summary: 3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
ht1	Wdfy3^em1(IMPC)Mbp/Wdfy3^+	C57BL/6N-Wdfy3^em1(IMPC)Mbp/MbpMmucd	MGI:6493194
ht2	Wdfy3^tm1a(KOMP)Mbp/Wdfy3^+	C57BL/6N-Wdfy3^tm1a(KOMP)Mbp	MGI:5825305
ht3	Wdfy3^disc/Wdfy3^+	involves: C57BL/6J * FVB/NJ	MGI:5825283

Genotype
MGI:6493194

ht1

• Allelic Composition: Wdfy3^em1(IMPC)Mbp/Wdfy3⁺
• Genetic Background: C57BL/6N-Wdfy3^em1(IMPC)Mbp/MbpMmucd

Data Sources

IMPC Data for Wdfy3

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

growth/size/body

enlarged liver ( J:211773 )

♂

IMPC - UCD

enlarged spleen ( J:211773 )

IMPC - UCD

hematopoietic system

abnormal spleen morphology ( J:211773 )

IMPC - UCD

enlarged spleen ( J:211773 )

IMPC - UCD

immune system

abnormal spleen morphology ( J:211773 )

IMPC - UCD

enlarged spleen ( J:211773 )

IMPC - UCD

abnormal lymph node morphology ( J:211773 )

♂

IMPC - UCD

enlarged lymph nodes ( J:211773 )

♂

IMPC - UCD

liver/biliary system

abnormal liver morphology ( J:211773 )

♂

IMPC - UCD

enlarged liver ( J:211773 )

♂

IMPC - UCD

renal/urinary system

abnormal kidney morphology ( J:211773 )

♂

IMPC - UCD

small kidney ( J:211773 )

♂

IMPC - UCD

Genotype
MGI:5825305

ht2

• Allelic Composition: Wdfy3^{tm1a(KOMP)Mbp}/Wdfy3⁺
• Genetic Background: C57BL/6N-Wdfy3^{tm1a(KOMP)Mbp}
• Cell Lines: DEPD00523_5_G11

nervous system

abnormal neocortex morphology ( J:225200 )

• newborn heterozygotes show a mild but significant (~19%) increase in neocortical length relative to wild-type controls, unlike Wdfy3^disc heterozygotes

• however, overall neocortical size is not significantly increased and no focal cortical dysplasias are observed

Genotype
MGI:5825283

ht3

• Allelic Composition: Wdfy3^disc/Wdfy3⁺
• Genetic Background: involves: C57BL/6J * FVB/NJ

normal phenotype

no abnormal phenotype detected ( J:225200 )

• mice are viable and fertile, lack overt neurodevelopmental anomalies, and show normal forebrain morphology at E18.5