About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Irf4+
wild type
MGI:2430024
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
ht1
 		Irf4M2Btlr/Irf4+ C57BL/6J-Irf4M2Btlr MGI:5789624
cx2
 		Col1a1tm1(tetO-Irf4)Sing/Col1a1tm1(tetO-Irf4)Sing
Gt(ROSA)26Sortm1(rtTA*M2)Jae/Gt(ROSA)26Sor+
Irf4tm1Mak/Irf4+ 		involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6 MGI:5529093


Genotype
MGI:5789624
ht1
Allelic
Composition		 Irf4M2Btlr/Irf4+
Genetic
Background		 C57BL/6J-Irf4M2Btlr
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Irf4M2Btlr mutation (0 available); any Irf4 mutation (34 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
abnormal B cell activation ( J:234245 )
• mice showed a slight diminish in T-dependent antibody response (IgG) to recombinant Semliki Forest virus (rSFV)-encoded beta-galactosidase (rSFV-beta-gal)
• mice showed a diminished T-independent antibody (IgM) response to 4-hydroxy-3-nitrophenylacetyl-Ficoll (NP-Ficoll)
decreased IgG level ( J:234245 )
• mice showed a slight diminish in T-dependent antibody response (IgG) to recombinant Semliki Forest virus (rSFV)-encoded beta-galactosidase (rSFV-beta-gal)
decreased IgM level ( J:234245 )
• mice showed a diminished T-independent antibody (IgM) response to 4-hydroxy-3-nitrophenylacetyl-Ficoll (NP-Ficoll)

hematopoietic system
abnormal B cell activation ( J:234245 )
• mice showed a slight diminish in T-dependent antibody response (IgG) to recombinant Semliki Forest virus (rSFV)-encoded beta-galactosidase (rSFV-beta-gal)
• mice showed a diminished T-independent antibody (IgM) response to 4-hydroxy-3-nitrophenylacetyl-Ficoll (NP-Ficoll)
decreased IgG level ( J:234245 )
• mice showed a slight diminish in T-dependent antibody response (IgG) to recombinant Semliki Forest virus (rSFV)-encoded beta-galactosidase (rSFV-beta-gal)
decreased IgM level ( J:234245 )
• mice showed a diminished T-independent antibody (IgM) response to 4-hydroxy-3-nitrophenylacetyl-Ficoll (NP-Ficoll)




Genotype
MGI:5529093
cx2
Allelic
Composition		 Col1a1tm1(tetO-Irf4)Sing/Col1a1tm1(tetO-Irf4)Sing
Gt(ROSA)26Sortm1(rtTA*M2)Jae/Gt(ROSA)26Sor+
Irf4tm1Mak/Irf4+
Genetic
Background		 involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Col1a1tm1(tetO-Irf4)Sing mutation (0 available); any Col1a1 mutation (166 available)
Gt(ROSA)26Sortm1(rtTA*M2)Jae mutation (31 available); any Gt(ROSA)26Sor mutation (1098 available)
Irf4tm1Mak mutation (2 available); any Irf4 mutation (34 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system
abnormal class switch recombination ( J:203903 )
• doxycycline-treated mice exhibit enhanced plasma cell generation at the expense of class switch recombination
abnormal plasma cell differentiation ( J:203903 )
• doxycycline-treated mice exhibit enhanced plasma cell generation at the expense of class switch recombination

immune system
abnormal class switch recombination ( J:203903 )
• doxycycline-treated mice exhibit enhanced plasma cell generation at the expense of class switch recombination
abnormal plasma cell differentiation ( J:203903 )
• doxycycline-treated mice exhibit enhanced plasma cell generation at the expense of class switch recombination




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
03/25/2025
MGI 6.24 		The Jackson Laboratory