All Phenotypes Nr4a2<tm1Niko> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Nr4a2^tm1Niko
targeted mutation 1, Vera M Nikodem
MGI:2429971

Summary

1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Nr4a2^tm1Niko/Nr4a2^tm1Niko	involves: 129S4/SvJae	MGI:3723184

Allelic Composition	Nr4a2^tm1Niko/Nr4a2^tm1Niko
Genetic Background	involves: 129S4/SvJae

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nr4a2^tm1Niko mutation (0 available); any Nr4a2 mutation (40 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

• mice appear dehydrated within 12 hours after birth, and soon die

homeostasis/metabolism

decreased dopamine level ( J:47684 )

• dopamine is absent in the substantia nigra and ventral tegmental area of mice

dehydration ( J:47684 )

nervous system

nervous system phenotype ( J:47684 )

N	• no differences are observed in cellularity, presence of neurons, or axonal projections to the substantia nigra or ventral tegmental area in mutants relative to wild-type

loss of dopaminergic neurons ( J:47684 )

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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