Phenotypes associated with this allele

• Allele Symbol: Dmd^tm1Mok
• Allele Name: targeted mutation 1, Motoya Katsuki
• Allele ID: MGI:2429942
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Dmd^tm1Mok/Dmd^tm1Mok	involves: 129S/SvEv	MGI:3722313
ot2	Dmd^tm1Mok/Y	involves: 129S/SvEv	MGI:3722314

Genotype
MGI:3722313

hm1

• Allelic Composition: Dmd^tm1Mok/Dmd^tm1Mok
• Genetic Background: involves: 129S/SvEv

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cellular

abnormal plasma membrane morphology ( J:102549 )

♀ • in the plasma membrane of the extensor digitorum longus, caveola density is increased while the density of intramembranous particles is decreased

Genotype
MGI:3722314

ot2

• Allelic Composition: Dmd^tm1Mok/Y
• Genetic Background: involves: 129S/SvEv

muscle

abnormal diaphragm morphology ( J:43164 )

♂ • at 4 and 4.5 months of age, the diaphragm exhibits an increase in connective tissue

muscle degeneration ( J:43164 )

♂ • at 4 and 4.5 months of age, dissected muscles are whitish and hypertrophic

♂ • several muscles exhibit an increase in size and an increase in connective tissue with necrotic fibers

♂ • muscle degeneration is similar to that observed in other Dmd deficient mice

cellular

abnormal plasma membrane morphology ( J:102549 )

♂ • in the plasma membrane of the extensor digitorum longus, caveola density is increased while the density of intramembranous particles is decreased

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
Duchenne muscular dystrophy		DOID:11723	OMIM:310200	J:43164