Phenotypes associated with this allele

• Allele Symbol: Glra1^nmf11
• Allele Name: neuroscience mutagenesis facility, 11
• Allele ID: MGI:2429918
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Glra1^nmf11/Glra1^nmf11	C57BL/6J-Glra1^nmf11/J	MGI:2429919

Genotype
MGI:2429919

hm1

• Allelic Composition: Glra1^nmf11/Glra1^nmf11
• Genetic Background: C57BL/6J-Glra1^nmf11/J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

premature death ( J:78134 )

• homozygotes are not viable

adipose tissue

decreased white adipose tissue amount ( J:78134 )

• little or no white fat was present

behavior/neurological

tremors ( J:78134 )

• tremors can be consistently induced by a light touch

abnormal gait ( J:78134 )

• unsteady gait that becomes detectable between 18-21 days of age

seizures ( J:78134 )

• gently dropping the animals from a height of 10-15cm onto a soft surface frequently induces seizure-like behavior

hematopoietic system

thymus atrophy ( J:78134 )

• atrophic thymus

small spleen ( J:78134 )

immune system

thymus atrophy ( J:78134 )

• atrophic thymus

small spleen ( J:78134 )

vision/eye

abnormal eye electrophysiology ( J:78134 )

• electroretinograms have shown abnormal b-waves in three (2 males, 1 female) of four mutants examined

nervous system

seizures ( J:78134 )

• gently dropping the animals from a height of 10-15cm onto a soft surface frequently induces seizure-like behavior

endocrine/exocrine glands

thymus atrophy ( J:78134 )

• atrophic thymus