Phenotypes associated with this allele

• Allele Symbol: Scn8a^6J
• Allele Name: 6 Jackson
• Allele ID: MGI:2429911
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Scn8a^6J/Scn8a^6J	C57BL/6J-Scn8a^6J/J	MGI:2429912

Genotype
MGI:2429912

hm1

• Allelic Composition: Scn8a^6J/Scn8a^6J
• Genetic Background: C57BL/6J-Scn8a^6J/J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

abnormal gait ( J:78134 )

• described as seal-like; onset of phenotype appears between 2 and 4 weeks of age

hindlimb paralysis ( J:90095 )

• bilateral hindlimb paralysis develops with age of onset at 20 +/- 3 days

growth/size/body

decreased body weight ( J:78134 )

• two of three mutant mice had significantly lower body weights

muscle

muscular atrophy ( J:90095 )

• standard pathological workup showed extensive atrophy of muscle fibers of the hind limb; central nuclei and rowing of the nuclei in longitudinal sections were also observed; whole muscle mounts of the hind limb stained with fluorescent-labeled bungarotoxin and SMI 31 revealed no abnormalities of neuromuscular junctions

mortality/aging

premature death ( J:90095 )

• a few homozygotes survive to 3 months of age, but most die before then

nervous system

nervous system phenotype ( J:90095 )

N • 2 homozygotes assessed at 3 months of age displayed normal EEG readings for more than 4 hours on two separate days with no indication of epileptic activity