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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Ryr3tm1Tno
targeted mutation 1, Tetsuo Noda
MGI:2429752
Summary 3 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Ryr3tm1Tno/Ryr3tm1Tno involves: 129S4/SvJae MGI:3623005
hm2
 		Ryr3tm1Tno/Ryr3tm1Tno involves: 129S4/SvJae * C57BL/6N MGI:3623009
ht3
 		Ryr3tm1Tno/Ryr3+ involves: 129S4/SvJae * C57BL/6N MGI:3623010


Genotype
MGI:3623005
hm1
Allelic
Composition		 Ryr3tm1Tno/Ryr3tm1Tno
Genetic
Background		 involves: 129S4/SvJae
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ryr3tm1Tno mutation (0 available); any Ryr3 mutation (261 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
behavior/neurological
hyperactivity ( J:34908 )
• homozygous mutants appear restless compared to littermates
increased locomotor activity ( J:34908 )
• mutants exhibit approximately 2-fold greater locomotor activity than heterozygotes or wild-type mice




Genotype
MGI:3623009
hm2
Allelic
Composition		 Ryr3tm1Tno/Ryr3tm1Tno
Genetic
Background		 involves: 129S4/SvJae * C57BL/6N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ryr3tm1Tno mutation (0 available); any Ryr3 mutation (261 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
behavior/neurological
impaired passive avoidance behavior ( J:61004 )
• homozygous mice show poor passive avoidance performance compared to wild-type
abnormal contextual conditioning behavior ( J:61004 )
• after a foot shock on Day 1, homozygotes show no decrease in locomotor activity on Day2 compared to wild-type which show decreased locomotor activity
abnormal spatial learning ( J:61004 )
• homozygous mutant mice display a low level of spontaneous alternation behavior in a Y-maze test compared to wild-type




Genotype
MGI:3623010
ht3
Allelic
Composition		 Ryr3tm1Tno/Ryr3+
Genetic
Background		 involves: 129S4/SvJae * C57BL/6N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ryr3tm1Tno mutation (0 available); any Ryr3 mutation (261 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
behavior/neurological
impaired passive avoidance behavior ( J:61004 )
• heterozygous mice show intermediate passive avoidance performance between homozygotes and wild-type
abnormal contextual conditioning behavior ( J:61004 )
• after a foot shock on Day 1, heterozygotes show an intermediate decrease in locomotor activity on Day2 compared to nulls and wild-type.
abnormal spatial learning ( J:61004 )
• heterozygotes display an intermediate level of spontaneous alternation behavior in a Y-maze test with respect to wild-type and nulls.




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
05/07/2024
MGI 6.23 		The Jackson Laboratory