All Phenotypes Brca2<tm2Mak> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Brca2^tm2Mak
targeted mutation 2, Tak W Mak
MGI:2429691

Summary

3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Brca2^tm2Mak/Brca2^tm2Mak	involves: 129P2/OlaHsd * C57BL/6	MGI:3831543
cn2	Brca2^tm1Mak/Brca2^tm2Mak Trp53^tm1Brd/Trp53^tm1Brd Tg(Lck-cre)548Jxm/0	involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6 * CBA	MGI:3831545
cn3	Brca2^tm1Mak/Brca2^tm2Mak Tg(Lck-cre)548Jxm/0	involves: 129P2/OlaHsd * C57BL/6 * CBA	MGI:3831544

Allelic Composition	Brca2^tm2Mak/Brca2^tm2Mak
Genetic Background	involves: 129P2/OlaHsd * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Brca2^tm2Mak mutation (1 available); any Brca2 mutation (132 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

normal phenotype

no abnormal phenotype detected ( J:79697 )

• mice are viable

Allelic Composition	Brca2^tm1Mak/Brca2^tm2Mak Trp53^tm1Brd/Trp53^tm1Brd Tg(Lck-cre)548Jxm/0
Genetic Background	involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6 * CBA

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Brca2^tm1Mak mutation (0 available); any Brca2 mutation (132 available)
Brca2^tm2Mak mutation (1 available); any Brca2 mutation (132 available)
Tg(Lck-cre)548Jxm mutation (2 available)
Trp53^tm1Brd mutation (5 available); any Trp53 mutation (232 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

immune system phenotype ( J:79697 )

N	• proliferating T cells fail to exhibit the same increase in spontaneous apoptosis observed in Brca2^tm1Mak/Brca2^tm2Mak Tg(Lck-cre)548Jxm mice

increased activated T cell number ( J:79697 )

• likely due to decreased apoptosis

neoplasm

increased tumor incidence ( J:79697 )

• tumorigenesis is accelerated compared to in wild-type and Trp53^tm1Brd/Trp53^tm1Brd Tg(Lck-cre)548Jxm mice but not compared to in Trp53^tm1Brd homozygotes

increased lymphoma incidence ( J:79697 )

• 90% of mice succumb to T-cell lymphomas compared to 70% of Trp53^tm1Brd/Trp53^tm1Brd Tg(Lck-cre)548Jxm mice

increased malignant tumor incidence ( J:79697 )

• mice develop high grade malignancies

increased osteosarcoma incidence ( J:79697 )

cellular

abnormal chromosome morphology ( J:79697 )

• T cells exhibit increased frequencies of chromatid or chromosomal breaks, tri-radial structures, and chromosomal fragments compared to in Brca2^tm1Mak/Brca2^tm2Mak Tg(Lck-cre)548Jxm mice or wild-type cells

decreased cellular sensitivity to ionizing radiation ( J:79697 )

• thymocytes are resistant to ionizing radiation-induced cell death unlike wild-type cells

• however, response to UV- or methyl methane sulfonate-induced cell death is normal

hematopoietic system

increased activated T cell number ( J:79697 )

• likely due to decreased apoptosis

skeleton

increased osteosarcoma incidence ( J:79697 )

Allelic Composition	Brca2^tm1Mak/Brca2^tm2Mak Tg(Lck-cre)548Jxm/0
Genetic Background	involves: 129P2/OlaHsd * C57BL/6 * CBA

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

immune system phenotype ( J:79697 )

N	• T cell development and proliferation are normal

increased T cell apoptosis ( J:79697 )

• proliferating T cells exhibit increased spontaneous apoptosis compared to wild-type cells

• however, apoptosis of activated T cells following exposure to ionizing radiation, adriamycin or FasL is normal

neoplasm

neoplasm ( J:79697 )

N	• mice do not develop tumors

cellular

cellular phenotype ( J:79697 )

N	• response to DNA damaging agents is normal

abnormal chromosome morphology ( J:79697 )

• T cells exhibit increased frequencies of chromatid or chromosomal breaks, tri-radial structures, and chromosomal fragments compared to in wild-type cells

aneuploidy ( J:79697 )

• 14.5% of T cells exhibit aneuploidy unlike wild-type cells

increased T cell apoptosis ( J:79697 )

• proliferating T cells exhibit increased spontaneous apoptosis compared to wild-type cells

• however, apoptosis of activated T cells following exposure to ionizing radiation, adriamycin or FasL is normal

hematopoietic system

increased T cell apoptosis ( J:79697 )

• proliferating T cells exhibit increased spontaneous apoptosis compared to wild-type cells

• however, apoptosis of activated T cells following exposure to ionizing radiation, adriamycin or FasL is normal

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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