Phenotypes associated with this allele

• Allele Symbol: Gja8^Aey5
• Allele Name: dominant cataract 5
• Allele ID: MGI:2429652
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Gja8^Aey5/Gja8^Aey5	C3HeB/FeJ-Gja8^Aey5	MGI:4450907
ht2	Gja8^Aey5/Gja8^+	C3HeB/FeJ-Gja8^Aey5	MGI:4450908

Genotype
MGI:4450907

hm1

• Allelic Composition: Gja8^Aey5/Gja8^Aey5
• Genetic Background: C3HeB/FeJ-Gja8^Aey5

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

vision/eye

abnormal lens fiber morphology ( J:74555 )

• at P4, mutant lenses display multiple clefts of various sizes in the embryonic nucleus, unlike wild-type lenses

• at P10, abnormal remnants of fiber cell nuclei persist in secondary fibers in the anterior lens region; in contrast, the cell nuclei of wild-type differentiating lens fibers are degraded normally

• by 7 weeks of age, the degenerated lens nucleus is separated from the cortical fibers indicating liquefaction of perinuclear lens fibers, unlike in wild-type lenses

cataract ( J:74555 )

• nuclear and posterior suture opacities are observed at eye opening (P12)

• opacities progress to cloudy nuclear and sharp zonular cataracts at 2 months of age

small lens ( J:74555 )

• cataractous lenses are smaller than wild-type

Genotype
MGI:4450908

ht2

• Allelic Composition: Gja8^Aey5/Gja8⁺
• Genetic Background: C3HeB/FeJ-Gja8^Aey5

vision/eye

abnormal lens fiber morphology ( J:74555 )

• at P4, mutant lenses display multiple clefts of various sizes in the embryonic nucleus, unlike wild-type lenses

• at P10, abnormal remnants of fiber cell nuclei persist in secondary fibers in the anterior lens region; in contrast, the cell nuclei of wild-type differentiating lens fibers are degraded normally

• by 7 weeks of age, the degenerated lens nucleus is separated from the cortical fibers indicating liquefaction of perinuclear lens fibers, unlike in wild-type lenses

cataract ( J:74555 )

• nuclear and posterior suture opacities are observed at eye opening (P12)

• opacities progress to cloudy nuclear and sharp zonular cataracts at 2 months of age

• no differences in onset or severity between heterozygous and homozygous mutant mice are observed

small lens ( J:74555 )

• cataractous lenses are smaller than wild-type