All Phenotypes Pou4f3<tm1Whk> MGI Mouse

• while the number of retinal ganglion cells are decreased the number of displaced amacrine cells is increased

• retina suffer a greater loss of projections emanating from the ventral-temporal region than from the dorsal-nasal region

increased amacrine cell number ( J:73779 )

• amacrine cells are increased in number

abnormal retina ganglion cell morphology ( J:73779 )

• cells of the retinal ganglion cell (RGC) layer are unable to extend processes and some subsequently undergo apoptosis

• reduction of axon outgrowth is more severe than in Pou4f3^tm1Kln homogygotes

• however, axons that are present are correctly routed

decreased retina ganglion cell number ( J:73779 )

• retinal ganglion cells are reduced to 60% of wild-type

• cells that normally express Pou4f3 experience increased apoptosis

• at 3 weeks, retinal ganglion cell number of the ventral-temporal region is 70% of the cells found in wild-type

• overall, retinal ganglion cells in the retina are reduced by 60% compared to the Pou4f3^tm1Kln homogygotes

thin retina ganglion layer ( J:73779 )

• the retinal ganglion cell (RGC) layer is composed of 2+/-2 RGCs with 90% of the layer being composed of amacrine cells compared to wild-type RGC layer which are composed of 15+/-3 RGCs and the layer of one third amacrine cells

abnormal retina nerve fiber layer morphology ( J:73779 )

• at 3 weeks, optic fibers are virtually absent

• however, axons that are present are routed correctly

deafness ( J:73779 )

abnormal vestibular system physiology ( J:73779 )

• mice have vestibular impairments that are more severe than in Pou4f3^tm1Kln homogygotes

abnormal sensory neuron innervation pattern ( J:73779 )

• at 3 weeks, loss of retinal ganglion cells projections emanating from the ventral-temporal region is greater than the loss of projections from the dorsal-nasal region