Phenotypes associated with this allele
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pou4f3tm1Whk mutation
(0 available);
any
Pou4f3 mutation
(25 available)
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hearing/vestibular/ear
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• mice have vestibular impairments that are less severe than in Pou4f3tm1Kln Pou4f2tm3Kln homogygotes
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• mice have vestibular impairments that are less severe than in Pou4f3tm1Kln Pou4f2tm3Kln homogygotes
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pou4f2tm3Whk mutation
(0 available);
any
Pou4f2 mutation
(7 available)
Pou4f3tm1Whk mutation
(0 available);
any
Pou4f3 mutation
(25 available)
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vision/eye
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• while the number of retinal ganglion cells are decreased the number of displaced amacrine cells is increased
• retina suffer a greater loss of projections emanating from the ventral-temporal region than from the dorsal-nasal region
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• amacrine cells are increased in number
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• cells of the retinal ganglion cell (RGC) layer are unable to extend processes and some subsequently undergo apoptosis
• reduction of axon outgrowth is more severe than in Pou4f3tm1Kln homogygotes
• however, axons that are present are correctly routed
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• retinal ganglion cells are reduced to 60% of wild-type
• cells that normally express Pou4f3 experience increased apoptosis
• at 3 weeks, retinal ganglion cell number of the ventral-temporal region is 70% of the cells found in wild-type
• overall, retinal ganglion cells in the retina are reduced by 60% compared to the Pou4f3tm1Kln homogygotes
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• the retinal ganglion cell (RGC) layer is composed of 2+/-2 RGCs with 90% of the layer being composed of amacrine cells compared to wild-type RGC layer which are composed of 15+/-3 RGCs and the layer of one third amacrine cells
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• at 3 weeks, optic fibers are virtually absent
• however, axons that are present are routed correctly
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hearing/vestibular/ear
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• mice have vestibular impairments that are more severe than in Pou4f3tm1Kln homogygotes
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nervous system
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• at 3 weeks, loss of retinal ganglion cells projections emanating from the ventral-temporal region is greater than the loss of projections from the dorsal-nasal region
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• amacrine cells are increased in number
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• cells of the retinal ganglion cell (RGC) layer are unable to extend processes and some subsequently undergo apoptosis
• reduction of axon outgrowth is more severe than in Pou4f3tm1Kln homogygotes
• however, axons that are present are correctly routed
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• retinal ganglion cells are reduced to 60% of wild-type
• cells that normally express Pou4f3 experience increased apoptosis
• at 3 weeks, retinal ganglion cell number of the ventral-temporal region is 70% of the cells found in wild-type
• overall, retinal ganglion cells in the retina are reduced by 60% compared to the Pou4f3tm1Kln homogygotes
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