All Phenotypes Mos<tm1Sia> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Mos^tm1Sia
targeted mutation 1, Shinichi Aizawa
MGI:2429547

Summary

1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Mos^tm1Sia/Mos^tm1Sia	involves: C57BL/6 * CBA	MGI:2663922

Allelic Composition	Mos^tm1Sia/Mos^tm1Sia
Genetic Background	involves: C57BL/6 * CBA

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mos^tm1Sia mutation (1 available); any Mos mutation (21 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

neoplasm

increased teratoma incidence ( J:19086 )

• high frequency of ovarian teratomas

reproductive system

abnormal female meiosis ( J:19086 )

• oocyte development failed to arrest during meiosis, leading to spontaneous parthenogenetic activation

female infertility ( J:19086 )

• 10 of 25 females tested were infertile

reduced female fertility ( J:19086 )

• females that are fertile have fewer and smaller litters compared with heterozygous females

decreased litter size ( J:19086 )

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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