Phenotypes associated with this allele

• Allele Symbol: Dst^tm1Efu
• Allele Name: targeted mutation 1, Elaine Fuchs
• Allele ID: MGI:2429314
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Dst^tm1Efu/Dst^tm1Efu	involves: C57BL/6	MGI:3819012

Genotype
MGI:3819012

hm1

• Allelic Composition: Dst^tm1Efu/Dst^tm1Efu
• Genetic Background: involves: C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

premature death ( J:24974 )

• mice are sacrificed at 5 to 6 weeks of age due to deteriorating condition

nervous system

abnormal myelin sheath morphology ( J:24974 )

• axon degeneration is followed by secondary degeneration of myelin sheaths

axon degeneration ( J:24974 )

• at 4 weeks of age, mice exhibit axonal degeneration that results in the loss of myelinated axons in the skin dermis

• axonal degeneration is observed in the sciatic nerve and peripheral nerves

• axon degeneration is followed by secondary degeneration of myelin sheaths

• degenerative changes occur in the gray matter of the brain and spinal cord

muscle

dystonia ( J:24974 )

muscular atrophy ( J:24974 )

• at 1 month of age, mice exhibit hind limb atrophy unlike in wild-type mice

behavior/neurological

impaired righting response ( J:24974 )

dystonia ( J:24974 )

homeostasis/metabolism

delayed wound healing ( J:24974 )

• mice exhibit delayed wound healing due to decreased keratinocyte migration into the wound compared to in wild-type mice

limbs/digits/tail

kinked tail ( J:24974 )

• at 1 month of age, mice exhibit kinked and rigid tails unlike in wild-type mice

integument

alopecia ( J:24974 )

• older mice exhibit hair loss in tuffs following gentle pulling unlike in wild-type mice

blistering ( J:24974 )

• unlike in wild-type mice, tail skin blisters as a result of mechanical stress

• blistering occurs from basal cells rupturing in a highly defined zone parallel to and just above cell base

• blistering in stratified squamous epithelia and in epidermis of haired skin is rare