Phenotypes associated with this allele
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
No mouse lines available in IMSR.
See publication links below for author information.
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mortality/aging
cardiovascular system
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• improved echocardiographic fractional shortening versus transgenic mice homozygous for Hrtfm4DBA/2J
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muscle
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• improved echocardiographic fractional shortening versus transgenic mice homozygous for Hrtfm4DBA/2J
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
No mouse lines available in IMSR.
See publication links below for author information.
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cardiovascular system
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• mice with the transgene and at least one AKR/J allele at Hrtfm5 exhibit improved echocardiographic fractional shortening and left ventricular diastolic diameter versus transgenic mice homozygous for Hrtfm5DBA/2J
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muscle
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• mice with the transgene and at least one AKR/J allele at Hrtfm5 exhibit improved echocardiographic fractional shortening and left ventricular diastolic diameter versus transgenic mice homozygous for Hrtfm5DBA/2J
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
No mouse lines available in IMSR.
See publication links below for author information.
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cardiovascular system
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• mice with the transgene and at least one AKR/J allele at Hrtfm6 exhibit improved fractional shortening and improved left ventricular diastolic diameter versus transgenic mice homozygous for Hrtfm6DBA/2J
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muscle
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• mice with the transgene and at least one AKR/J allele at Hrtfm6 exhibit improved fractional shortening and improved left ventricular diastolic diameter versus transgenic mice homozygous for Hrtfm6DBA/2J
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(Myh6-CASQ2)1Mord mutation
(0 available)
Tnni3kA mutation
(0 available);
any
Tnni3k mutation
(43 available)
Tnni3kB mutation
(0 available);
any
Tnni3k mutation
(43 available)
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cardiovascular system
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• reduced fractional shortening at age 4 and 8 weeks
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mortality/aging
muscle
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• reduced fractional shortening at age 4 and 8 weeks
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(Myh6-CASQ2)1Mord mutation
(0 available)
Tnni3kB mutation
(0 available);
any
Tnni3k mutation
(43 available)
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
No mouse lines available in IMSR.
See publication links below for author information.
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mortality/aging
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• increased survival versus transgenic mice homozygous for Hrtfm3DBA/2J
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(Myh6-CASQ2)1Mord mutation
(0 available)
Tg(Myh6-TNNI3K)#Dmar mutation
(0 available)
Tnni3kB mutation
(0 available);
any
Tnni3k mutation
(43 available)
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cardiovascular system
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• reduced fractional shortening at around age 14 days
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mortality/aging
muscle
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• reduced fractional shortening at around age 14 days
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
No mouse lines available in IMSR.
See publication links below for author information.
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mortality/aging
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• all mice die by 16 weeks of age
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cardiovascular system
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• at 7 and 14 weeks of age, total beta-adrenergic receptor density and the number of high affinity receptors are reduced in hearts
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• ventricular myocytes are larger and have a distinctive appearance with blurred striations
• myocytes are filled with a large number of membrane-limited vesicles which pervade the entire cell outline, displacing myofibrils and mitochondria
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• mice show mild chamber enlargement at 7 weeks of age and severe cardiac enlargement at 14 weeks of age
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• severe hypertrophy, with a 2-fold increase in heart mass and cell size
(J:46786)
• mice initially exhibit cardiac hypertrophy
(J:79838)
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• progressive increase in left ventricular mass from 7 to 14 weeks of age
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• left ventricular wall thickness is increased at 7 weeks of age but at 14 weeks, wall thickness is reduced to normal values
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• cardiac hypertrophy is accompanied by focal areas of fibrosis
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• mice initially exhibit cardiac hypertrophy with only a mild reduction in systolic function that progresses to severe cardiac enlargement and left ventricular dysfunction with premature death
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• mice show progressive deterioration of cardiac function, showing an increase in left ventricular end-diastolic diameter, a decrease in % fractional shortening, and reduction in wall thickness from 7 to 14 weeks
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• first derivative of left ventricular pressure rise (LV dP/dt max) is reduced in 7 week old mice, indicating decreased basal contractility
• mice undergoing right atrial pacing to match heart rate to that of wild-type mice do not exhibit an increase in left ventricular dP/dt max but instead a decline
• hearts of 7 week old mice show a blunted response to isoproterenol
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• myocardial relaxation assessed by LV dP/dt min is impaired in 7 and 14 week old mice under basal conditions
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• echocardiography indicates increased wall thickness progressing to left ventricular enlargement and severe cardiac dysfunction
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• left ventricular systolic pressure is only slightly reduced in 7 week old mice and is reduced in 14 week old mice
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• heart rate is lower at base line and with isoproterenol in 7 and 14 week old mice
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• cardiac hypertrophy is accompanied by rapid heart rate
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• in whole cell-clamped myocytes, calcium-channel-gated calcium release from the sarcoplasmic reticulum is suppressed, the frequency of occurrence of spontaneous or calcium current-triggered 'calcium-sparks' is reduced and the spark perimeter is less defined
• caffeine-induced calcium transients and the resultant sodium-calcium exchanger currents are increased 10-fold in myocytes
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homeostasis/metabolism
respiratory system
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• increase in the respiratory rate
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muscle
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• ventricular myocytes are larger and have a distinctive appearance with blurred striations
• myocytes are filled with a large number of membrane-limited vesicles which pervade the entire cell outline, displacing myofibrils and mitochondria
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• mice initially exhibit cardiac hypertrophy with only a mild reduction in systolic function that progresses to severe cardiac enlargement and left ventricular dysfunction with premature death
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• mice show progressive deterioration of cardiac function, showing an increase in left ventricular end-diastolic diameter, a decrease in % fractional shortening, and reduction in wall thickness from 7 to 14 weeks
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• first derivative of left ventricular pressure rise (LV dP/dt max) is reduced in 7 week old mice, indicating decreased basal contractility
• mice undergoing right atrial pacing to match heart rate to that of wild-type mice do not exhibit an increase in left ventricular dP/dt max but instead a decline
• hearts of 7 week old mice show a blunted response to isoproterenol
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• myocardial relaxation assessed by LV dP/dt min is impaired in 7 and 14 week old mice under basal conditions
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• junctions between the sarcoplasmic reticulum and the surface membrane, or peripheral couplings, and between the sarcoplasmic reticulum and T tubules are less frequent than in wild-type myocardium
• the junctions are smaller and the junctional sarcoplasmic reticulum is enlarged and the calsequestrin content is more dispersed
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growth/size/body
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• mice show mild chamber enlargement at 7 weeks of age and severe cardiac enlargement at 14 weeks of age
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• severe hypertrophy, with a 2-fold increase in heart mass and cell size
(J:46786)
• mice initially exhibit cardiac hypertrophy
(J:79838)
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Analysis Tools