Phenotypes associated with this allele

• Allele Symbol: Cox17^tm1Kako
• Allele Name: targeted mutation 1, Koichiro Kako
• Allele ID: MGI:2388937
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Cox17^tm1Kako/Cox17^tm1Kako	involves: 129X1/SvJ * C57BL/6J	MGI:3510402

Genotype
MGI:3510402

hm1

• Allelic Composition: Cox17^tm1Kako/Cox17^tm1Kako
• Genetic Background: involves: 129X1/SvJ * C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

embryonic lethality during organogenesis, complete penetrance ( J:79609 )

• homozygotes develop normally until E6.5 but die between E8.5 and E10

cellular

abnormal mitochondrial ATP synthesis coupled electron transport ( J:79609 )

• at E6.5, mutant embryos display severe reductions in cytochrome c oxidase (CCO) activity; the immunoreactivity of other COX subunits remains unaffected

• reduced CCO activity in embryonic and extraembryonic tissues is also observed at later stages of development

embryo

embryonic growth arrest ( J:79609 )

• at E7.5, mutant embryos appear severely retarded and more fragile upon dissection of the decidua

abnormal embryonic tissue morphology ( J:79609 )

• at E8.5, the mutant embryonic region is smaller than the extraembryonic region, and the embryonic cavity is severely reduced

• at E8.5, many embryonic cells appear small and atrophic relative to wild-type; the presence of condensed nuclei suggests apoptosis

homeostasis/metabolism

homeostasis/metabolism phenotype ( J:79609 )

N • at E6.5, homozygotes exhibit normal succinate dehydrogenase activity as well as normal lactate dehydrogenase activity, suggesting normal glycolysis