Phenotypes associated with this allele

• Allele Symbol: Spta1^sph-Dem
• Allele Name: spherocytosis-Demant
• Allele ID: MGI:2388936
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Spta1^sph-Dem/Spta1^sph-Dem	CcS3/Dem-Spta1^sph-Dem	MGI:3845547

Genotype
MGI:3845547

hm1

• Allelic Composition: Spta1^sph-Dem/Spta1^sph-Dem
• Genetic Background: CcS3/Dem-Spta1^sph-Dem

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

hematopoietic system

enlarged spleen ( J:66966 )

anemia ( J:66966 )

• the RBC count is 48% of normal

• hematocrit value is 57% of normal

• hemoglobin value is 38% of normal

abnormal erythrocyte morphology ( J:62355 )

• cell surface expression of phosphatidylserine is much higher than in wild-type controls or in other hemolytic anemia mutants, with 37.1% of erythrocytes straining positive for phosphatidylserine versus 1.6% in wild-type controls

elliptocytosis ( J:62355 , J:66966 )

microcytosis ( J:62355 )

• the percentage of erythroid cells that are microcytes is much larger than in wild-type controls

cellular

renal necrosis ( J:66966 )

growth/size/body

enlarged spleen ( J:66966 )

immune system

enlarged spleen ( J:66966 )

liver/biliary system

liver degeneration ( J:66966 )

• seen in neonates

jaundice ( J:66966 )

• neonates are obviously yellow in color

renal/urinary system

renal necrosis ( J:66966 )

homeostasis/metabolism

abnormal cardiac thrombosis ( J:62355 )

• 95% of homozygotes display cardiac thrombi