Phenotypes associated with this allele
|
|
| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nfatc4tm1Jmk mutation
(1 available);
any
Nfatc4 mutation
(36 available)
|
|
|
cardiovascular system
|
N |
• normal ventricular trabeculation
• normal thickening of compact zone
|
|
|
• response to abdominal aortic constriction or continuous infusion of angiotensin II identical to controls
• increased heart weight/tibia length ratio when treated as above
|
growth/size/body
|
|
• response to abdominal aortic constriction or continuous infusion of angiotensin II identical to controls
• increased heart weight/tibia length ratio when treated as above
|
mortality/aging
|
|
• embryos either necrotic or resorbed at E11.5
• no live embryos after E11.5
|
cardiovascular system
|
|
• thin and translucent at E10.5
• pericardial effusions
|
|
|
• more than 50% reduction in proliferation at E10.5
• no apoptosis
|
|
|
• restricted to mitochondria in the heart
• ventricular myocardium with enlarged and disorganized mitochondria
• defects in cristae formation, fewer in number or absent
• ventricular mitochondria with dilated tubules or onion-like swirls
|
|
|
• more than 50% reduction in the number of cells
|
|
|
• defects in cardiac development at E10.5
|
|
|
• ventricular myocardium with enlarged and disorganized mitochondria
• defects in cristae formation, fewer in number or absent
• ventricular mitochondria with dilated tubules or onion-like swirls
|
|
|
• fewer in number
• thinner
|
|
|
• 30% reduction in mitochondrial respiration
|
cellular
|
|
• restricted to mitochondria in the heart
• ventricular myocardium with enlarged and disorganized mitochondria
• defects in cristae formation, fewer in number or absent
• ventricular mitochondria with dilated tubules or onion-like swirls
|
|
|
• 30% reduction in mitochondrial respiration
|
hematopoietic system
embryo
|
|
• mild generalized developmental delay at E10.5
• head, tail and limb buds normal at E10.5
|
growth/size/body
|
|
• mild generalized developmental delay at E10.5
• head, tail and limb buds normal at E10.5
|
muscle
|
|
• more than 50% reduction in proliferation at E10.5
• no apoptosis
|
|
|
• restricted to mitochondria in the heart
• ventricular myocardium with enlarged and disorganized mitochondria
• defects in cristae formation, fewer in number or absent
• ventricular mitochondria with dilated tubules or onion-like swirls
|
|
|
• thinner
• fewer in number
|
|
|
• more than 50% reduction in the number of cells
|
cardiovascular system
|
|
• reduced number of smooth muscle cells in the dorsal aorta but no hemorrhage
|
|
|
| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nfatc3tm1Glm mutation
(1 available);
any
Nfatc3 mutation
(70 available)
Nfatc4tm1Jmk mutation
(1 available);
any
Nfatc4 mutation
(36 available)
Tg(Myh6-NFATC4)#Eno mutation
(0 available)
|
|
|
mortality/aging
|
|
• viability extended to around E12
• no live embryos at E12.5 or later
|
cardiovascular system
|
N |
• normal heart phenotype at E11.5
• heart mitochondrial respiration normal at E10.5
• 70% of mitochondria are normal in heart muscle at E10.5
|
|
|
| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nfatc4tm1Jmk mutation
(1 available);
any
Nfatc4 mutation
(36 available)
Tg(Myh6-Ppp3ca)37Eno mutation
(1 available)
|
|
|
cardiovascular system
|
|
• myofibrillar hypertrophy
|
|
|
• identical to control mice with the transgene alone
• three fold increase in heart/body weight ratio
• wall thickening
|
muscle
|
|
• myofibrillar hypertrophy
|
growth/size/body
|
|
• identical to control mice with the transgene alone
• three fold increase in heart/body weight ratio
• wall thickening
|
Analysis Tools