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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Tg(Lck-Map3k8)3456Ngc
transgene insertion 3456, Neal G Copeland
MGI:2388710
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
tg1
 		Tg(Lck-Map3k8)3456Ngc/? involves: C3H/HeJ * C57BL/6J MGI:2389022


Genotype
MGI:2389022
tg1
Allelic
Composition		 Tg(Lck-Map3k8)3456Ngc/?
Genetic
Background		 involves: C3H/HeJ * C57BL/6J
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♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
neoplasm
increased T cell derived lymphoma incidence ( J:39450 )
• mice developed metastatic lymphoblastic lymphomas with an 88% incidence by 3 months of age
• tumors were shown to be of T-cell origin derived from cells at different stages of T-cell development

endocrine/exocrine glands
increased T cell derived lymphoma incidence ( J:39450 )
• mice developed metastatic lymphoblastic lymphomas with an 88% incidence by 3 months of age
• tumors were shown to be of T-cell origin derived from cells at different stages of T-cell development




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
05/07/2024
MGI 6.23 		The Jackson Laboratory