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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Tcrgtm2.1Dhr
targeted mutation 2.1, David H Raulet
MGI:2388612
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Tcrgtm2.1Dhr/Tcrgtm2.1Dhr involves: 129S4/SvJae * C57BL/6 MGI:3813518
cx2
 		Tcrdtm1Mom/Tcrdtm1Mom
Tcrgtm2.1Dhr/Tcrgtm2.1Dhr 		involves: 129 * C57BL/6 MGI:3813519


Genotype
MGI:3813518
hm1
Allelic
Composition		 Tcrgtm2.1Dhr/Tcrgtm2.1Dhr
Genetic
Background		 involves: 129S4/SvJae * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tcrgtm2.1Dhr mutation (0 available); any Tcrg mutation (1 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
abnormal T cell receptor gamma chain V-J recombination ( J:75624 )
• Vgamma2 rearrangement is reduced by 2.6-fold in the adult thymus
• Vgamma3 and Vgamma4 rearrangments are reduced by 2- to 4-fold in fetal thymocytes
abnormal gamma-delta T cell differentiation ( J:75624 )
• there is a 15-fold reduction reduction in the number of precursor gammadelta T cells in the adult thymus that express Vgamma2
• there is about a 20-fold reduction in precursor gammadelta T cells expressing Vgamma3 among E15 fetal thymocytes and a 5- to 10- fold reduction among E17 fetal thymocytes

hematopoietic system
abnormal T cell receptor gamma chain V-J recombination ( J:75624 )
• Vgamma2 rearrangement is reduced by 2.6-fold in the adult thymus
• Vgamma3 and Vgamma4 rearrangments are reduced by 2- to 4-fold in fetal thymocytes
abnormal gamma-delta T cell differentiation ( J:75624 )
• there is a 15-fold reduction reduction in the number of precursor gammadelta T cells in the adult thymus that express Vgamma2
• there is about a 20-fold reduction in precursor gammadelta T cells expressing Vgamma3 among E15 fetal thymocytes and a 5- to 10- fold reduction among E17 fetal thymocytes




Genotype
MGI:3813519
cx2
Allelic
Composition		 Tcrdtm1Mom/Tcrdtm1Mom
Tcrgtm2.1Dhr/Tcrgtm2.1Dhr
Genetic
Background		 involves: 129 * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tcrdtm1Mom mutation (13 available); any Tcrd mutation (15 available)
Tcrgtm2.1Dhr mutation (0 available); any Tcrg mutation (1 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
abnormal T cell receptor gamma chain V-J recombination ( J:75624 )
• Vgamma2 rearrangement is reduced by 2-fold in the adult thymus compared to Tcrdtm1Mom homozygotes

hematopoietic system
abnormal T cell receptor gamma chain V-J recombination ( J:75624 )
• Vgamma2 rearrangement is reduced by 2-fold in the adult thymus compared to Tcrdtm1Mom homozygotes




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
05/14/2024
MGI 6.23 		The Jackson Laboratory