Phenotypes associated with this allele

• Allele Symbol: Tnfsf10^tm1Sdg
• Allele Name: targeted mutation 1, Lisa M Sedger
• Allele ID: MGI:2388390
• Summary: 3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Tnfsf10^tm1Sdg/Tnfsf10^tm1Sdg	B6.129-Tnfsf10^tm1Sdg	MGI:3706169
hm2	Tnfsf10^tm1Sdg/Tnfsf10^tm1Sdg	C.129-Tnfsf10^tm1Sdg	MGI:3706168
hm3	Tnfsf10^tm1Sdg/Tnfsf10^tm1Sdg	involves: 129 * C57BL/6	MGI:3713754

Genotype
MGI:3706169

hm1

• Allelic Composition: Tnfsf10^tm1Sdg/Tnfsf10^tm1Sdg
• Genetic Background: B6.129-Tnfsf10^tm1Sdg

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

neoplasm

neoplasm ( J:79085 )

N • Background Sensitivity: unlike mice on a BALB/c congenic background, mice on a C57BL/6 congenic background show no difference from controls in the rate of A20 lymphoma tumor progression

immune system

immune system phenotype ( J:79085 )

N • despite the potential contribution of genetic epistatic factors toautoimmune disease, no signs of lymphoproliferative disease are detected

Genotype
MGI:3706168

hm2

• Allelic Composition: Tnfsf10^tm1Sdg/Tnfsf10^tm1Sdg
• Genetic Background: C.129-Tnfsf10^tm1Sdg

mortality/aging

increased susceptibility to induced morbidity/mortality ( J:79085 )

• exposure of mice to A20 tumor cells results in increased mortality (70% of mutants survive at day 100 compared to 100 wild-type)

• at higher doses of A20 tumor cells the difference is more pronounced (30% of nulls survive at day 100 compared to 100% wild-type at a dose of 10³ A20 tumor cells)

• Background Sensitivity: unlike mice on a congenic C57BL/6 background, mice on a congenic BALB/c background display an impaired ability to control A20 lymphoma progression compared to wild-type mice

neoplasm

increased tumor growth/size ( J:79085 )

• 40 days after tumor cell injection, a threefold increase in A20 tumor nodules is seen in the liver

• Background Sensitivity: unlike mice on a congenic C57BL/6 background, mice on a congenic BALB/c background display an impaired ability to control A20 lymphoma progression compared to wild-type mice

Genotype
MGI:3713754

hm3

• Allelic Composition: Tnfsf10^tm1Sdg/Tnfsf10^tm1Sdg
• Genetic Background: involves: 129 * C57BL/6

immune system

immune system phenotype ( J:79085 )

N • all lymphoid tissues and cell numbers of myeloid, lymphoid, and immature erythroid cell subpopulations are similar to controls

skeleton

skeleton phenotype ( J:79085 )

N • despite the fact that this protein binds to osteoprotegrin, bone biology is normal and mice are not osteopetrotic