All Phenotypes Hoxa11<tm2.1(Hoxa13)Ssp> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Hoxa11^{tm2.1(Hoxa13)Ssp}
targeted mutation 2.1, S Steven Potter
MGI:2388357

Summary

5 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Hoxa11^{tm2.1(Hoxa13)Ssp}/Hoxa11^{tm2.1(Hoxa13)Ssp}	either: (involves: 129P2/OlaHsd) or (involves: 129S1/Sv * 129X1/SvJ)	MGI:3810946
ht2	Hoxa11^{tm2.1(Hoxa13)Ssp}/Hoxa11⁺	either: (involves: 129P2/OlaHsd) or (involves: 129S1/Sv * 129X1/SvJ)	MGI:3810947
ht3	Hoxa11^tm1Ssp/Hoxa11^{tm2.1(Hoxa13)Ssp}	either: (involves: 129P2/OlaHsd * 129S2/SvPas) or (involves: 129S1/Sv * 129S2/SvPas * 129X1/SvJ)	MGI:3810952
cx4	Hoxa11^tm1Ssp/Hoxa11^{tm2.1(Hoxa13)Ssp} Hoxd11^tm1Mrc/Hoxd11⁺	either: (involves: 129P2/OlaHsd * 129S2/SvPas * 129S7/SvEvBrd) or (involves: 129S1/Sv * 129S2/SvPas * 129S7/SvEvBrd * 129X1/SvJ)	MGI:3810948
cx5	Hoxa11^tm1Ssp/Hoxa11^{tm2.1(Hoxa13)Ssp} Hoxd11^tm1Mrc/Hoxd11^tm1Mrc	either: (involves: 129P2/OlaHsd * 129S2/SvPas * 129S7/SvEvBrd) or (involves: 129S1/Sv * 129S2/SvPas * 129S7/SvEvBrd * 129X1/SvJ)	MGI:3810949

Allelic Composition	Hoxa11^{tm2.1(Hoxa13)Ssp}/Hoxa11^{tm2.1(Hoxa13)Ssp}
Genetic Background	either: (involves: 129P2/OlaHsd) or (involves: 129S1/Sv * 129X1/SvJ)

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hoxa11^{tm2.1(Hoxa13)Ssp} mutation (0 available); any Hoxa11 mutation (11 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

limbs/digits/tail

abnormal carpal bone morphology ( J:71402 )

• the styloid apophyses is reduced and/or fused to the ulna and radius

abnormal calcaneum morphology ( J:71402 )

• the calcaneus bone is reduced to the length of the tarsus unlike in wild-type mice

abnormal talus morphology ( J:71402 )

abnormal forelimb zeugopod morphology ( J:71402 )

• shortened and malformed

short radius ( J:71402 )

short ulna ( J:71402 )

abnormal hindlimb zeugopod morphology ( J:71402 )

• mice exhibit a separation in the distal tibia and fibula unlike in wild-type mice

renal/urinary system

renal/urinary system phenotype ( J:71402 )

N	• kidney development is normal

reproductive system

reproductive system phenotype ( J:71402 )

N	• male mice are fertile with normal male reproductive anatomy

abnormal endometrium morphology ( J:71402 )

• mice exhibit multi-layered epithelium and a more fibrous stromal layer indicating a posteriorization to cervix compared to in wild-type mice

absent endometrial glands ( J:71402 )

• mice lack endometrial glands in the uterine lining

female infertility ( J:71402 )

skeleton

skeleton phenotype ( J:71402 )

N	• mice do not exhibit the thoracic transformation observed in Hoxa11^tm1Ssp homozygotes

abnormal carpal bone morphology ( J:71402 )

• the styloid apophyses is reduced and/or fused to the ulna and radius

abnormal calcaneum morphology ( J:71402 )

• the calcaneus bone is reduced to the length of the tarsus unlike in wild-type mice

abnormal talus morphology ( J:71402 )

short radius ( J:71402 )

short ulna ( J:71402 )

endocrine/exocrine glands

absent endometrial glands ( J:71402 )

• mice lack endometrial glands in the uterine lining

Allelic Composition	Hoxa11^{tm2.1(Hoxa13)Ssp}/Hoxa11⁺
Genetic Background	either: (involves: 129P2/OlaHsd) or (involves: 129S1/Sv * 129X1/SvJ)

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hoxa11^{tm2.1(Hoxa13)Ssp} mutation (0 available); any Hoxa11 mutation (11 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

reproductive system

absent endometrial glands ( J:71402 )

• mice lack uterine glands

female infertility ( J:71402 )

limbs/digits/tail

limbs/digits/tail phenotype ( J:71402 )

N	• forelimb morphology is normal

abnormal calcaneum morphology ( J:71402 )

• 7% of mice exhibit a reduction in the calcaneus bone compared to in wild-type mice

abnormal hindlimb zeugopod morphology ( J:71402 )

• mice exhibit a separation in the distal tibia and fibula unlike in wild-type mice

skeleton

abnormal calcaneum morphology ( J:71402 )

• 7% of mice exhibit a reduction in the calcaneus bone compared to in wild-type mice

endocrine/exocrine glands

absent endometrial glands ( J:71402 )

• mice lack uterine glands

Allelic Composition	Hoxa11^tm1Ssp/Hoxa11^{tm2.1(Hoxa13)Ssp}
Genetic Background	either: (involves: 129P2/OlaHsd * 129S2/SvPas) or (involves: 129S1/Sv * 129S2/SvPas * 129X1/SvJ)

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hoxa11^tm1Ssp mutation (0 available); any Hoxa11 mutation (11 available)
Hoxa11^{tm2.1(Hoxa13)Ssp} mutation (0 available); any Hoxa11 mutation (11 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

limbs/digits/tail

abnormal calcaneum morphology ( J:71402 )

• 33% of mice exhibit a reduction in the calcaneus bone compared to in wild-type mice

abnormal forelimb zeugopod morphology ( J:71402 )

• shortened and malformed

skeleton

abnormal calcaneum morphology ( J:71402 )

• 33% of mice exhibit a reduction in the calcaneus bone compared to in wild-type mice

reproductive system

female infertility ( J:71402 )

Allelic Composition	Hoxa11^tm1Ssp/Hoxa11^{tm2.1(Hoxa13)Ssp} Hoxd11^tm1Mrc/Hoxd11⁺
Genetic Background	either: (involves: 129P2/OlaHsd * 129S2/SvPas * 129S7/SvEvBrd) or (involves: 129S1/Sv * 129S2/SvPas * 129S7/SvEvBrd * 129X1/SvJ)

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

limbs/digits/tail

abnormal calcaneum morphology ( J:71402 )

• 72% of mice exhibit a reduction in the calcaneus bone compared to in wild-type mice

abnormal forelimb zeugopod morphology ( J:71402 )

• shortened and malformed

reproductive system

reproductive system phenotype ( J:71402 )

N	• male mice are fertile

female infertility ( J:71402 )

skeleton

abnormal calcaneum morphology ( J:71402 )

• 72% of mice exhibit a reduction in the calcaneus bone compared to in wild-type mice

Allelic Composition	Hoxa11^tm1Ssp/Hoxa11^{tm2.1(Hoxa13)Ssp} Hoxd11^tm1Mrc/Hoxd11^tm1Mrc
Genetic Background	either: (involves: 129P2/OlaHsd * 129S2/SvPas * 129S7/SvEvBrd) or (involves: 129S1/Sv * 129S2/SvPas * 129S7/SvEvBrd * 129X1/SvJ)

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

decreased survivor rate ( J:71402 )

• some mice die prior to P30

premature death ( J:71402 )

• some mice die prior to P30

postnatal lethality, incomplete penetrance ( J:71402 )

• some mice die prior to P30

limbs/digits/tail

abnormal carpal bone morphology ( J:71402 )

• the styloid apophyses is severely reduced and/or fused to the ulna and radius

abnormal calcaneum morphology ( J:71402 )

• all mice exhibit a reduction in the calcaneus bone compared to in wild-type mice

abnormal forelimb zeugopod morphology ( J:71402 )

• shortened and malformed

renal/urinary system

abnormal kidney morphology ( J:71402 )

• mice exhibit an indentation in the anterior region of the left kidney unlike in wild-type mice

kidney cyst ( J:71402 )

• one pair in eight pairs of kidneys exhibit small cysts

kidney medulla hypoplasia ( J:71402 )

• the medulla layer is smaller and more disorganized than in wild-type mice

abnormal renal tubule morphology ( J:71402 )

• proximal tubule lumens are more distinct than in Hoxa11^tm1Ssp Hoxd11^tm1Mrc homozygotes

dilated renal tubule ( J:71402 )

• mice exhibit fewer dilated tubules than in Hoxa11^tm1Ssp Hoxd11^tm1Mrc homozygotes

skeleton

abnormal carpal bone morphology ( J:71402 )

• the styloid apophyses is severely reduced and/or fused to the ulna and radius

abnormal calcaneum morphology ( J:71402 )

• all mice exhibit a reduction in the calcaneus bone compared to in wild-type mice

reproductive system

female infertility ( J:71402 )

growth/size/body

kidney cyst ( J:71402 )

• one pair in eight pairs of kidneys exhibit small cysts

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