Phenotypes associated with this allele

• Allele Symbol: Kirrel1^{Gt(VICTR20)20Lex}
• Allele Name: gene trap 20, Lexicon Genetics
• Allele ID: MGI:2388348
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Kirrel1^Gt(VICTR20)20Lex/Kirrel1^Gt(VICTR20)20Lex	involves: 129S5/SvEvBrd * C57BL/6	MGI:3036181

Genotype
MGI:3036181

hm1

• Allelic Composition: Kirrel1^{Gt(VICTR20)20Lex}/Kirrel1^{Gt(VICTR20)20Lex}
• Genetic Background: involves: 129S5/SvEvBrd * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

premature death ( J:74230 )

• a few survive as long as 3-8 weeks

postnatal lethality, incomplete penetrance ( J:74230 )

• most homozygous mice die between P1 and P12

growth/size/body

renal glomerulus cyst ( J:74230 )

• occasional cystic glomeruli

decreased body size ( J:74230 )

• homozygous mice are described as small and sickly; they fail to thrive by 1 week of age

renal/urinary system

renal glomerulus cyst ( J:74230 )

• occasional cystic glomeruli

increased urine protein level ( J:74230 )

• heavy proteinuria; 300-2000 mg/dl compared to negligible amounts or up to 30 mg/dl in controls

abnormal renal glomerulus morphology ( J:74230 )

• dilated juxtamedullary glomeruli and occasional cystic glomeruli

increased mesangial cell number ( J:74230 )

• diffuse mesangial hypercellularity

expanded mesangial matrix ( J:74230 )

• increased mesangial matrix

mesangiolysis ( J:74230 )

• occasional mesangiolysis

dilated proximal convoluted tubule ( J:74230 )

• proximal tubules focally dilated

homeostasis/metabolism

increased urine protein level ( J:74230 )

• heavy proteinuria; 300-2000 mg/dl compared to negligible amounts or up to 30 mg/dl in controls

cellular

increased mesangial cell number ( J:74230 )

• diffuse mesangial hypercellularity