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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Eportm2Jni
targeted mutation 2, James N Ihle
MGI:2388346
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Eportm2Jni/Eportm2Jni involves: 129P2/OlaHsd * C57BL/6 MGI:3706820
cx2
 		Dyrk3tm1Dowo/Dyrk3tm1Dowo
Eportm2Jni/Eportm2Jni 		involves: 129P2/OlaHsd * C57BL/6 * FVB/N MGI:3831652


Genotype
MGI:3706820
hm1
Allelic
Composition		 Eportm2Jni/Eportm2Jni
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Eportm2Jni mutation (0 available); any Epor mutation (25 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system
abnormal erythropoiesis ( J:70036 )
• the numbers of erythroid burst-forming-units (BFU-E) are reduced in fetal liver cell preparations relative to wild-type
decreased hematocrit ( J:70036 )
• embryos at E14.5, E15.5, and E18.5, and adults show lower hematocrits than wild-type
• challenging mutants with continuous injections of Epo results in a lower rate of increase in hematocrit than in wild-type or homozygous Eportm1Jni mutants




Genotype
MGI:3831652
cx2
Allelic
Composition		 Dyrk3tm1Dowo/Dyrk3tm1Dowo
Eportm2Jni/Eportm2Jni
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6 * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dyrk3tm1Dowo mutation (0 available); any Dyrk3 mutation (34 available)
Eportm2Jni mutation (0 available); any Epor mutation (25 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system
abnormal stress erythropoiesis ( J:144586 )
• stress-induced erythropoiesis using 5-fluorouracil is increased compared to in similarly treated Eportm2Jni mice




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
05/21/2024
MGI 6.23 		The Jackson Laboratory