All Phenotypes Rag1<tm1(GFP)Imku> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Rag1^tm1(GFP)Imku
targeted mutation 1, Nobuo Sakaguchi
MGI:2388344

Summary

3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Rag1^tm1(GFP)Imku/Rag1^tm1(GFP)Imku	involves: C57BL/6 * CBA	MGI:3838850
cx2	Inpp5d^tm1Rkh/Inpp5d^tm1Rkh Rag1^tm1(GFP)Imku/Rag1⁺	involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA	MGI:3838991
cx3	Rag1^tm1(GFP)Imku/? Zfp335^blt/Zfp335^blt	involves: C57BL/6 * CBA	MGI:5604147

Allelic Composition	Rag1^tm1(GFP)Imku/Rag1^tm1(GFP)Imku
Genetic Background	involves: C57BL/6 * CBA

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rag1^tm1(GFP)Imku mutation (0 available); any Rag1 mutation (120 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

abnormal immunoglobulin V(D)J recombination ( J:79416 )

• bone marrow B cells lack recombination of the immunoglobulin gene segments

hematopoietic system

abnormal immunoglobulin V(D)J recombination ( J:79416 )

• bone marrow B cells lack recombination of the immunoglobulin gene segments

Allelic Composition	Inpp5d^tm1Rkh/Inpp5d^tm1Rkh Rag1^tm1(GFP)Imku/Rag1⁺
Genetic Background	involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Inpp5d^tm1Rkh mutation (0 available); any Inpp5d mutation (93 available)
Rag1^tm1(GFP)Imku mutation (0 available); any Rag1 mutation (120 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

hematopoietic system

abnormal lymphopoiesis ( J:117320 )

• there is a defect in development of early-lymphoid progenitors

• no GFP-positive cells are observed in the Lin^-c-Kit^hiSca-1⁺ cell population in the bone marrow compared 9% of the population being GFP-positive in Rag1^tm1(GFP)Imku heterozygotes

• there is a 10-fold decrease in Lin^-c-Kit^loSca-1^loGFP⁺ population in the bone marrow, corresponding to the prolymphocyte fraction

immune system

abnormal lymphopoiesis ( J:117320 )

• there is a defect in development of early-lymphoid progenitors

• no GFP-positive cells are observed in the Lin^-c-Kit^hiSca-1⁺ cell population in the bone marrow compared 9% of the population being GFP-positive in Rag1^tm1(GFP)Imku heterozygotes

• there is a 10-fold decrease in Lin^-c-Kit^loSca-1^loGFP⁺ population in the bone marrow, corresponding to the prolymphocyte fraction

Allelic Composition	Rag1^tm1(GFP)Imku/? Zfp335^blt/Zfp335^blt
Genetic Background	involves: C57BL/6 * CBA

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rag1^tm1(GFP)Imku mutation (0 available); any Rag1 mutation (120 available)
Zfp335^blt mutation (1 available); any Zfp335 mutation (67 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

hematopoietic system

abnormal CD4-positive T cell differentiation ( J:214793 )

• high rate of decay of recent thymic emigrants (RTE) in spleen and lymph nodes as compared to heterozygous controls, suggesting a block in post-thymic naive T cell maturation

immune system

abnormal CD4-positive T cell differentiation ( J:214793 )

• high rate of decay of recent thymic emigrants (RTE) in spleen and lymph nodes as compared to heterozygous controls, suggesting a block in post-thymic naive T cell maturation

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