Phenotypes associated with this allele

• Allele Symbol: Gfi1b^tm1Sho
• Allele Name: targeted mutation 1, Stuart Orkin
• Allele ID: MGI:2388162
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Gfi1b^tm1Sho/Gfi1b^tm1Sho	involves: 129S1/Sv	MGI:3640471

Genotype
MGI:3640471

hm1

• Allelic Composition: Gfi1b^tm1Sho/Gfi1b^tm1Sho
• Genetic Background: involves: 129S1/Sv

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

lethality throughout fetal growth and development, complete penetrance ( J:74523 )

• embryos die by E15

hematopoietic system

abnormal megakaryocyte differentiation ( J:74523 )

• development of megakaryocytes is also blocked but myeloid lineage is normal in fetal livers

abnormal erythropoiesis ( J:74523 )

• hematopoietic cells in the liver commit to the erythroid lineage but fail to mature into adult red blood cells

absent erythrocytes ( J:74523 )

• lack adult enucleated red blood cells

abnormal embryonic erythrocyte morphology ( J:74523 )

• less dense nuclei and more basophilic cytoplasm in primitive erythrocytes at E9.5-E10.5 indicative of retarded overall maturation

• primitive erythrocytes at E9.5-E10.5 with extensive membrane blebbing and ruffling

abnormal embryonic erythropoiesis ( J:74523 )

• abnormal primitive erythropoiesis

cardiovascular system

hemorrhage ( J:74523 )

• observed in embryos at E13.5-E14.5

homeostasis/metabolism

edema ( J:74523 )

• observed in embryos at E13.5-E14.5

embryo

abnormal embryonic erythropoiesis ( J:74523 )

• abnormal primitive erythropoiesis

integument

pallor ( J:74523 )

• observed in embryos at E13.5-E14.5

cellular

abnormal megakaryocyte differentiation ( J:74523 )

• development of megakaryocytes is also blocked but myeloid lineage is normal in fetal livers