Phenotypes associated with this allele

• Allele Symbol: Fxr2^tm1Cgr
• Allele Name: targeted mutation 1, Ben Oostra
• Allele ID: MGI:2388128
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Fxr2^tm1Cgr/Fxr2^tm1Cgr	involves: 129S7/SvEvBrd * C57BL/6J * FVB	MGI:2672023

Genotype
MGI:2672023

hm1

• Allelic Composition: Fxr2^tm1Cgr/Fxr2^tm1Cgr
• Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J * FVB

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

abnormal spatial learning ( J:75389 )

• swim distance and time to locate hidden plateforms are significantly greater in a Morris water maze test

• use a spatially biased search strategy however

decreased fear-related response ( J:75389 )

• impaired context related fear responses

abnormal motor capabilities/coordination/movement ( J:75389 )

impaired coordination ( J:75389 )

• performance on a rotarod significantly poorer than controls although improvement with testing is comparable

hyperactivity ( J:75389 )

• more active in open field tests than controls

increased locomotor activity ( J:75389 )

• travel greater distances, spend more time in motion, travel faster

increased thermal nociceptive threshold ( J:75389 )

• less sensitive to painful stimuli in a hot plate test

nervous system

decreased prepulse inhibition ( J:75389 )

• decreased prepulse inhibition although startle response is normal

reproductive system

reproductive system phenotype ( J:75389 )

N • no abnormal reproductive system phenotypes detected