Phenotypes associated with this allele

• Allele Symbol: Smarcb1^{Gt(OST32815)Lex}
• Allele Name: gene trap OST32815, Lexicon Genetics
• Allele ID: MGI:2388033
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Smarcb1^Gt(OST32815)Lex/Smarcb1^Gt(OST32815)Lex	either: (involves: 129 * 129S5/SvEvBrd) or (involves: 129S5/SvEvBrd * C57BL/6)	MGI:3035817
ht2	Smarcb1^Gt(OST32815)Lex/Smarcb1^+	either: (involves: 129 * 129S5/SvEvBrd) or (involves: 129S5/SvEvBrd * C57BL/6)	MGI:3035818

Genotype
MGI:3035817

hm1

• Allelic Composition: Smarcb1^{Gt(OST32815)Lex}/Smarcb1^{Gt(OST32815)Lex}
• Genetic Background: either: (involves: 129 * 129S5/SvEvBrd) or (involves: 129S5/SvEvBrd * C57BL/6)

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

embryonic lethality at implantation, complete penetrance ( J:69009 )

• embryos exhibit peri-implantation lethality between E3.5 and E5.5

embryo

absent inner cell mass proliferation ( J:69009 )

• the ICM did not expand in cultured homozygous embryos

absent trophectoderm cell proliferation ( J:69009 )

• the trophectoderm did not expand in cultured homozygous embryos

failure of blastocyst to hatch from the zona pellucida ( J:69009 )

• blastocysts do not hatch from the zona pellucida

reproductive system

failure of embryo implantation ( J:69009 )

♀ • blastocysts do not hatch from the zona pellucida and do not implant in vitro

cellular

absent inner cell mass proliferation ( J:69009 )

• the ICM did not expand in cultured homozygous embryos

absent trophectoderm cell proliferation ( J:69009 )

• the trophectoderm did not expand in cultured homozygous embryos

Genotype
MGI:3035818

ht2

• Allelic Composition: Smarcb1^{Gt(OST32815)Lex}/Smarcb1⁺
• Genetic Background: either: (involves: 129 * 129S5/SvEvBrd) or (involves: 129S5/SvEvBrd * C57BL/6)

neoplasm

increased tumor incidence ( J:69009 , J:87955 )

• 15% of heterozygous mice develop tumors; primarily these are located on the head and neck; the majority of these tumors were poorly differentiated sarcomas with variable rhabdoid features (J:69009)