All Phenotypes Six4<tm1Kwk> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Six4^tm1Kwk
targeted mutation 1, Kiyoshi Kawakami
MGI:2388027

Summary

2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Six4^tm1Kwk/Six4^tm1Kwk	involves: 129P2/OlaHsd * C57BL/6	MGI:3036367
cx2	Six1^tm1Kwk/Six1^tm1Kwk Six4^tm1Kwk/Six4^tm1Kwk	involves: 129P2/OlaHsd	MGI:3612545

Allelic Composition	Six4^tm1Kwk/Six4^tm1Kwk
Genetic Background	involves: 129P2/OlaHsd * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Six4^tm1Kwk mutation (0 available); any Six4 mutation (36 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

normal phenotype

no abnormal phenotype detected ( J:69010 )

• viable and fertile; no gross morphological or histological abnormalities, or defects in hearing ability were detected in homozygous mice

Allelic Composition	Six1^tm1Kwk/Six1^tm1Kwk Six4^tm1Kwk/Six4^tm1Kwk
Genetic Background	involves: 129P2/OlaHsd

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Six1^tm1Kwk mutation (0 available); any Six1 mutation (18 available)
Six4^tm1Kwk mutation (0 available); any Six4 mutation (36 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

neonatal lethality, complete penetrance ( J:103002 )

• die soon after birth and show developmental defects in various organs

nervous system

abnormal dorsal root ganglion morphology ( J:103002 )

• exhibit developmental abnormalities of the dorsal root ganglia

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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