Phenotypes associated with this allele
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sortm1(rtTA,EGFP)Nagy mutation
(5 available);
any
Gt(ROSA)26Sor mutation
(942 available)
Sox9tm3(cre)Crm mutation
(1 available);
any
Sox9 mutation
(32 available)
Tg(tetO-Vegfa)1Kesh mutation
(0 available)
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cardiovascular system
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• the vascular network of the limbs is denser and more complex
• metacarpal centers are enriched for thicker vessels originating from the axial artery
• metacarpal centers are wider and split into a denser and more complex network of small capillaries in the interdigital areas
• however, formation of avascular areas is not affected
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(Myh6-tTA)6Smbf mutation
(4 available)
Tg(tetO-Vegfa)1Kesh mutation
(0 available)
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cardiovascular system
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• mesenchymal transformation and cellularization of the cardiac jelly are completely blocked in about half of E10.5 embryos
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• outflow tract development is impaired with cardiac jelly remaining empty by the time it is colonized with mesenchymal cells in controls
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• exhibit abnormal cardiac development upon tetracycline treatment to induce early expression of Vegfa
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• multi-layered endocardium
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Analysis Tools