About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Mbd3tm1Bh
targeted mutation 1, Brian Hendrich
MGI:2388006
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Mbd3tm1Bh/Mbd3tm1Bh involves: 129P2/OlaHsd * C57BL/6 MGI:3579840
cx2
 		Mbd2tm1Bh/Mbd2tm1Bh
Mbd3tm1Bh/Mbd3+ 		involves: 129P2/OlaHsd * C57BL/6 MGI:3579841


Genotype
MGI:3579840
hm1
Allelic
Composition		 Mbd3tm1Bh/Mbd3tm1Bh
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mbd3tm1Bh mutation (0 available); any Mbd3 mutation (56 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
embryonic lethality between implantation and somite formation, complete penetrance ( J:68356 )
• no normal embryos detectable after implantation
• at E8.5, embryos are severely retarded and undergoing resorption
• no live homozygotes born




Genotype
MGI:3579841
cx2
Allelic
Composition		 Mbd2tm1Bh/Mbd2tm1Bh
Mbd3tm1Bh/Mbd3+
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mbd2tm1Bh mutation (1 available); any Mbd2 mutation (21 available)
Mbd3tm1Bh mutation (0 available); any Mbd3 mutation (56 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
prenatal lethality, incomplete penetrance ( J:68356 )
• surviving heterozygotes reduced by 30% from expected




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
09/30/2025
MGI 6.24 		The Jackson Laboratory