Phenotypes associated with this allele

• Allele Symbol: Zfr^tm1Reb
• Allele Name: targeted mutation 1, Robert E Braun
• Allele ID: MGI:2387996
• Summary: 3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Zfr^tm1Reb/Zfr^tm1Reb	involves: 129S4/SvJae * 129X1/SvJ	MGI:2653371
hm2	Zfr^tm1Reb/Zfr^tm1Reb	involves: 129S4/SvJae * 129X1/SvJ * C57BL/6	MGI:2653372
hm3	Zfr^tm1Reb/Zfr^tm1Reb	involves: 129X1/SvJ * C57BL/6	MGI:2653373

Genotype
MGI:2653371

hm1

• Allelic Composition: Zfr^tm1Reb/Zfr^tm1Reb
• Genetic Background: involves: 129S4/SvJae * 129X1/SvJ

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

embryonic lethality between somite formation and embryo turning, complete penetrance ( J:68369 )

• death by E8 to E9

embryo

abnormal gastrulation ( J:68369 )

• impaired

decreased embryo size ( J:68369 )

• evident at E7.5, embryos were smaller, thinner, developmentally retarded

abnormal embryonic tissue morphology ( J:68369 )

• increased cell death in epiblast, evident at E6.5

• decreased cellular proliferation results in growth retardation at primitive streak stage; however, primitive streak formation, mesoderm differentiation and migration are not impaired

abnormal visceral endoderm morphology ( J:68369 )

• decreased vacuolization in visceral endoderm at E6.5

growth/size/body

decreased embryo size ( J:68369 )

• evident at E7.5, embryos were smaller, thinner, developmentally retarded

Genotype
MGI:2653372

hm2

• Allelic Composition: Zfr^tm1Reb/Zfr^tm1Reb
• Genetic Background: involves: 129S4/SvJae * 129X1/SvJ * C57BL/6

mortality/aging

embryonic lethality between somite formation and embryo turning, complete penetrance ( J:68369 )

• death by E8 to E9

embryo

abnormal gastrulation ( J:68369 )

• impaired

decreased embryo size ( J:68369 )

• evident at E7.5, embryos were smaller, thinner, developmentally retarded

abnormal embryonic tissue morphology ( J:68369 )

• increased cell death in epiblast, evident at E6.5

• decreased cellular proliferation results in growth retardation at primitive streak stage; however, primitive streak formation, mesoderm differentiation and migration are not impaired

abnormal visceral endoderm morphology ( J:68369 )

• decreased vacuolization in visceral endoderm at E6.5

growth/size/body

decreased embryo size ( J:68369 )

• evident at E7.5, embryos were smaller, thinner, developmentally retarded

Genotype
MGI:2653373

hm3

• Allelic Composition: Zfr^tm1Reb/Zfr^tm1Reb
• Genetic Background: involves: 129X1/SvJ * C57BL/6

mortality/aging

embryonic lethality between somite formation and embryo turning, complete penetrance ( J:68369 )

• death by E8 to E9

embryo

abnormal gastrulation ( J:68369 )

• impaired

decreased embryo size ( J:68369 )

• evident at E7.5, embryos were smaller, thinner, developmentally retarded

abnormal embryonic tissue morphology ( J:68369 )

• increased cell death in epiblast, evident at E6.5

• decreased cellular proliferation results in growth retardation at primitive streak stage; however, primitive streak formation, mesoderm differentiation and migration are not impaired

abnormal visceral endoderm morphology ( J:68369 )

• decreased vacuolization in visceral endoderm at E6.5

growth/size/body

decreased embryo size ( J:68369 )

• evident at E7.5, embryos were smaller, thinner, developmentally retarded