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Allele Symbol Allele Name Allele ID |
Mmp11tm1Mrio targeted mutation 1, Marie-Christine Rio MGI:2387934 |
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| Summary |
3 genotypes
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• lower death rate and a reduced number and size of DMBA-induced carcinomas
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• lower death rate and a reduced number and size of DMBA-induced carcinomas
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• exhibit significantly enhanced neointimal formation 2-3 weeks after electric injury of the femoral artery compared to wild-type
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• exhibit significantly enhanced neointimal formation 2-3 weeks after electric injury of the femoral artery compared to wild-type
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• all mutants developed mammary gland tumors however the average age of tumor onset was 37 weeks compared to 25 weeks in control transgenic mice that are wildtype for Mmp11
• mean time required to develop detectable tumor after the first pregnancy was about 10 weeks longer than in control transgenic mice that are wildtype for Mmp11
• decreased invasive primary tumor incidence compared to control transgenic mice that are wildtype for Mmp11
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• 69% developed lung metastases compared to 31% of control transgenic mice that are wildtype for Mmp11
• higher total number of metastases compared to transgenic mice that are wildtype for Mmp11
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• mean tumor number per mouse was about 40% lower than in control transgenic mice that are wildtype for Mmp11
• mean total tumor volume was about 2-fold lower than in control transgenic mice that are wildtype for Mmp11
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• developed tumors of various sizes that corresponded to moderately to poorly differentiated invasive duct carcinomas with most tumors growing as solid areas that contained no stroma
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• all mutants developed mammary gland tumors however the average age of tumor onset was 37 weeks compared to 25 weeks in control transgenic mice that are wildtype for Mmp11
• mean time required to develop detectable tumor after the first pregnancy was about 10 weeks longer than in control transgenic mice that are wildtype for Mmp11
• decreased invasive primary tumor incidence compared to control transgenic mice that are wildtype for Mmp11
|
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• all mutants developed mammary gland tumors however the average age of tumor onset was 37 weeks compared to 25 weeks in control transgenic mice that are wildtype for Mmp11
• mean time required to develop detectable tumor after the first pregnancy was about 10 weeks longer than in control transgenic mice that are wildtype for Mmp11
• decreased invasive primary tumor incidence compared to control transgenic mice that are wildtype for Mmp11
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 04/23/2024 MGI 6.23 |
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