Analysis Tools
behavior/neurological
| N |
• improgan and DPDPE analgesic responses are normal
|
|
Allele Symbol Allele Name Allele ID |
Oprd1tm1Jep targeted mutation 1, John E Pintar MGI:2387891 |
||||||||||||||||
| Summary |
3 genotypes
|
|
|
| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
| N |
• improgan and DPDPE analgesic responses are normal
|
|
|
| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
|
• compared to control, no significant differences in the global withdrawal score under the same chronic treatment of morphine
• develop a level of physical dependence that is at least comparable with that of wild-type mice control
|
|
• do not develop analgesic tolerance to morphine
|
|
|
| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
| N |
• mice exhibit normal nociception prior to opioid infusion
|
|
• unlike in wild-type mice, mice exhibit decreased tail-withdrawal latencies demonstrating the abolishment of opioid analgesic responses to acute doses of morphine and oxymorphone
• infusion of morphine results in a decrease in tail withdrawal latency relative to baseline after 2 days unlike similarly treated wild-type mice that display an increase on the first two days and a decrease on days 4 through 7
• infusion of oxymorphone results in reduced tail withdrawal latency compared to baseline at 4 days unlike in similarly treated wild-type mice that exhibit an increase in latency within the first 4 days and a decrease on days 8 through 10
• NMDA receptor blockage with MK-801 does not reverse opioid hyperalgesia unlike in similarly treated wild-type mice
|
|
• unlike in wild-type mice, mice exhibit decreased tail-withdrawal latencies demonstrating the abolishment of opioid analgesic responses to acute doses of morphine and oxymorphone
• infusion of morphine results in a decrease in tail withdrawal latency relative to baseline after 2 days unlike similarly treated wild-type mice that display an increase on the first two days and a decrease on days 4 through 7
• infusion of oxymorphone results in reduced tail withdrawal latency compared to baseline at 4 days unlike in similarly treated wild-type mice that exhibit an increase in latency within the first 4 days and a decrease on days 8 through 10
• NMDA receptor blockage with MK-801 does not reverse opioid hyperalgesia unlike in similarly treated wild-type mice
|
|
• NMDA receptor blockage with MK-801 does not reverse opioid hyperalgesia unlike in similarly treated wild-type mice
|
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
||
|
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support. |
last database update 04/23/2024 MGI 6.23 |
|
|
|
||