Phenotypes associated with this allele

• Allele Symbol: Tnni3^tm1Jww
• Allele Name: targeted mutation 1, Jeffery W Walker
• Allele ID: MGI:2387868
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Tnni3^tm1Jww/Tnni3^tm1Jww	Not Specified	MGI:2655972

Genotype
MGI:2655972

hm1

• Allelic Composition: Tnni3^tm1Jww/Tnni3^tm1Jww
• Genetic Background: Not Specified

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cellular

decreased myocardial fiber myofibril length ( J:53628 )

• ventricular myocytes show shortened sacromeres after P14

mortality/aging

postnatal lethality, complete penetrance ( J:53628 )

• mice died of acute heart failure 17 to 18 days after birth

cardiovascular system

abnormal lung vasculature morphology ( J:53628 )

• exhibit enlarged and congested pulmonary capillaries at P17-P18

abnormal myocardium layer morphology ( J:53628 )

• cardiac muscle shows a 47% increase in mitochondria numbers and a trend toward larger individual mitochondria

decreased myocardial fiber myofibril length ( J:53628 )

• ventricular myocytes show shortened sacromeres after P14

abnormal cardiovascular system physiology ( J:53628 )

• isolated ventricular myocytes show elevated resting tension measured under relaxing conditions and have a reduced myofilament calcium sensitivity of tension under activating conditions

congestive heart failure ( J:53628 )

• acute heart failure with congested pulmonary capillaries

behavior/neurological

lethargy ( J:53628 )

• develops on P18

muscle

abnormal myocardium layer morphology ( J:53628 )

• cardiac muscle shows a 47% increase in mitochondria numbers and a trend toward larger individual mitochondria

decreased myocardial fiber myofibril length ( J:53628 )

• ventricular myocytes show shortened sacromeres after P14

abnormal sarcomere morphology ( J:53628 )

• ventricular myocytes show shortened sacromeres after P14

respiratory system

abnormal lung vasculature morphology ( J:53628 )

• exhibit enlarged and congested pulmonary capillaries at P17-P18

respiratory distress ( J:53628 )

• develops on P18