Phenotypes associated with this allele
Allelic
Composition |
Ogttm1Gwh/Y
|
|
Genetic
Background |
involves: 129S1/Sv * 129X1/SvJ |
|
| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ogttm1Gwh mutation
(2 available);
any
Ogt mutation
(11 available)
|
|
|
cellular
 |
• recombined embryonic stem cells are found at 24 and 48 h following cre transduction but by 144 h all viable cells carry the unrecombined allele
(J:62279)
• primary embryonic fibroblasts infected with viral cre senesce and die by 12 days after infection
(J:93112)
|
|
|
• primary embryonic fibroblasts infected with viral cre do not form colonies of more than 10 cells indicating a failure to undergo 4 or more cell divisions
|
normal phenotype
 |
• mice are viable and fertile with no gross abnormalities and expression levels of Ogt that are similar to controls suggesting inactivation of the paternal X chromosome in all tissues and cell types surveyed
• mice do not produce any offspring carrying the recombined allele
|
mortality/aging
|
|
• no mice carrying the recombined allele are detected
|
mortality/aging
|
|
• no mice carrying the recombined allele are detected
|
mortality/aging
|
|
• when the cre is inherited maternally, no mice carrying the recombined allele are detected
|
reproductive system
|
|
• when the cre is inherited paternally mice survive but females are infertile
|
|
|
| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ogttm1Gwh mutation
(2 available);
any
Ogt mutation
(11 available)
Tg(Syn1-cre)671Jxm mutation
(1 available)
|
|
|
mortality/aging
|
|
• none survive for more than 10 days
|
behavior/neurological
|
|
• fail to develop normal locomotor activity
|
growth/size/body
|
|
| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ogttm1Gwh mutation
(2 available);
any
Ogt mutation
(11 available)
Tg(Lck-cre)548Jxm mutation
(2 available)
|
|
|
immune system
|
|
• increase in annexin-V expression in single positive T cells
|
|
|
• about a 75% reduction in the number of T cells in the lymph nodes and spleen
• no T cells carrying the recombined allele are found in the lymph nodes or spleen
|
|
|
• about a 50% reduction in thymocyte cell number
|
|
|
• cortical double positive T cells are reduced by 50%
|
hematopoietic system
|
|
• increase in annexin-V expression in single positive T cells
|
|
|
• about a 75% reduction in the number of T cells in the lymph nodes and spleen
• no T cells carrying the recombined allele are found in the lymph nodes or spleen
|
|
|
• about a 50% reduction in thymocyte cell number
|
|
|
• cortical double positive T cells are reduced by 50%
|
cellular
|
|
• increase in annexin-V expression in single positive T cells
|
endocrine/exocrine glands
|
|
• about a 50% reduction in thymocyte cell number
|
|
|
| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ogttm1Gwh mutation
(2 available);
any
Ogt mutation
(11 available)
Tg(Syn1-cre)671Jxm mutation
(1 available)
|
|
|
mortality/aging
|
|
• none survive for more than 10 days
|
|
|
• found at only about 50% of the expected frequency
|
behavior/neurological
|
|
• fail to develop normal locomotor activity
|
growth/size/body
Analysis Tools