Phenotypes associated with this allele

• Allele Symbol: Clip2^tm1.1Gal
• Allele Name: targeted mutation 1.1, Niels Galjart
• Allele ID: MGI:2387833
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Clip2^tm1.1Gal/Clip2^tm1.1Gal	involves: 129P2/OlaHsd * C57BL/6	MGI:3620029
ht2	Clip2^tm1.1Gal/Clip2^+	involves: 129P2/OlaHsd * C57BL/6	MGI:3620031

Genotype
MGI:3620029

hm1

• Allelic Composition: Clip2^tm1.1Gal/Clip2^tm1.1Gal
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

growth/size/body

decreased body weight ( J:78711 )

• adult female weight is 15% lower than in wild-type

decreased body length ( J:78711 )

• 11% decrease in adult female body length

postnatal growth retardation ( J:78711 )

• seen in both males and females

nervous system

dilated brain ventricle ( J:78711 )

• average brain-ventricle volume is larger

decreased corpus callosum size ( J:78711 )

• average corpus callosum volume is smaller

impaired synaptic plasticity ( J:78711 )

• synaptic plasticity in the hippocampal CA1 region is lower

behavior/neurological

behavior/neurological phenotype ( J:78711 )

N • no differences from wild-type are seen in spontaneous locomotion, the hanging wire test measuring balance and grip strength, the beam-walk test, and compensatory eye movements during visual or vestibular stimulation

abnormal contextual conditioning behavior ( J:78711 )

• in a contextual fear-conditioning test, show a smaller increase in average freezing time after foot shock than in wild-type, however no differences are seen in a cued fear-conditioning test or elevated zero-maze test, indicating hippocampal defects

impaired coordination ( J:78711 )

• remain on an accelerating rotarod for significantly shorter periods and exhibit poor initial coordination on a running wheel, showing highly erratic motions and occasional ejection from the wheel

cellular

abnormal cell morphology ( J:78711 )

• fibroblasts exhibit a higher level of dynactin and restin at microtubule tips, however observe no differences in microtubule dynamics

skeleton

abnormal skeleton morphology ( J:78711 )

• lower weight in females is paralleled by shorter bone lengths, however observe no craniofacial irregularities

Genotype
MGI:3620031

ht2

• Allelic Composition: Clip2^tm1.1Gal/Clip2⁺
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6

growth/size/body

decreased body weight ( J:78711 )

• adult female weight is 9% lower than in wild-type

postnatal growth retardation ( J:78711 )

• mild growth retardation during the first weeks of postnatal development that persists in adult females

nervous system

decreased corpus callosum size ( J:78711 )

• average corpus callosum volume is smaller, however ventricle volumes are normal

impaired synaptic plasticity ( J:78711 )

• synaptic plasticity in the hippocampal CA1 region is lower

behavior/neurological

abnormal contextual conditioning behavior ( J:78711 )

• in a contextual fear-conditioning test, show a smaller increase in average freezing time after foot shock than in wild-type, however no differences are seen in a cued fear-conditioning test or elevated zero-maze test, indicating hippocampal defects

impaired coordination ( J:78711 )

• remain on an accelerating rotarod for significantly shorter periods

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
Williams-Beuren syndrome		DOID:1928	OMIM:194050	J:78711