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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		H2az1tm1Ily
targeted mutation 1, Ian Lyons
MGI:2387764
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		H2az1tm1Ily/H2az1tm1Ily C.129P2-H2az1tm1Ily MGI:3623496


Genotype
MGI:3623496
hm1
Allelic
Composition		 H2az1tm1Ily/H2az1tm1Ily
Genetic
Background		 C.129P2-H2az1tm1Ily
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
H2az1tm1Ily mutation (1 available); any H2az1 mutation (14 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
embryonic lethality between implantation and somite formation, complete penetrance ( J:71146 )
• homozygotes normal at E4.5 but have all disappeared by E7.5

embryo
abnormal inner cell mass morphology ( J:71146 )
• cells derived from the inner cell mass of cultured blastocysts fail to persist whereas trophectoderm does persist




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
12/30/2025
MGI 6.24 		The Jackson Laboratory