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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		St3gal1tm1Jxm
targeted mutation 1, Jamey Marth
MGI:2387752
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cx1
 		Clec10atm1Hed/Clec10atm1Hed
St3gal1tm1Jxm/St3gal1tm1Jxm 		involves: 129S1/Sv * 129X1/SvJ * C57BL/6J MGI:3850151
cx2
 		Clec10atm1Hed/Clec10a+
St3gal1tm1Jxm/St3gal1tm1Jxm 		involves: 129S1/Sv * 129X1/SvJ * C57BL/6J MGI:3850152


Genotype
MGI:3850151
cx1
Allelic
Composition		 Clec10atm1Hed/Clec10atm1Hed
St3gal1tm1Jxm/St3gal1tm1Jxm
Genetic
Background		 involves: 129S1/Sv * 129X1/SvJ * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Clec10atm1Hed mutation (3 available); any Clec10a mutation (22 available)
St3gal1tm1Jxm mutation (0 available); any St3gal1 mutation (41 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system
decreased CD8-positive, alpha-beta T cell number ( J:78035 )
• although at 3 and 5 weeks of age, female (but not male) double homozygotes show a significant increase of CD8-positive T-cell numbers in the periphery relative to mice that are heterozygous for Mgl1tm1Hed and homozygous for St3gal1tm1Jxm, double homozygotes still exhibit a profound CD8 T-cell deficiency relative to wild-type mice

immune system
decreased CD8-positive, alpha-beta T cell number ( J:78035 )
• although at 3 and 5 weeks of age, female (but not male) double homozygotes show a significant increase of CD8-positive T-cell numbers in the periphery relative to mice that are heterozygous for Mgl1tm1Hed and homozygous for St3gal1tm1Jxm, double homozygotes still exhibit a profound CD8 T-cell deficiency relative to wild-type mice




Genotype
MGI:3850152
cx2
Allelic
Composition		 Clec10atm1Hed/Clec10a+
St3gal1tm1Jxm/St3gal1tm1Jxm
Genetic
Background		 involves: 129S1/Sv * 129X1/SvJ * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Clec10atm1Hed mutation (3 available); any Clec10a mutation (22 available)
St3gal1tm1Jxm mutation (0 available); any St3gal1 mutation (41 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system
decreased CD8-positive, alpha-beta T cell number ( J:78035 )
• at 3 to 6 weeks of age, mutant mice exhibit a variable reduction in the percentage of CD8 T cells in peripheral blood relative to heterozygous St3gal1tm1Jxm control mice (1-5% vs 11%, respectively)

immune system
decreased CD8-positive, alpha-beta T cell number ( J:78035 )
• at 3 to 6 weeks of age, mutant mice exhibit a variable reduction in the percentage of CD8 T cells in peripheral blood relative to heterozygous St3gal1tm1Jxm control mice (1-5% vs 11%, respectively)




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
04/23/2024
MGI 6.23 		The Jackson Laboratory