Analysis Tools
mortality/aging
|
• die between E9.5 and E10.5
|
|
Allele Symbol Allele Name Allele ID |
Zeb2tm1.2Yhi targeted mutation 1.2, Yujiro Higashi MGI:2387501 |
||||||||||||||||||||||||||||||||
| Summary |
7 genotypes
|
|
|
| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
|
• die between E9.5 and E10.5
|
|
|
| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
|
• die sometime around E9.5
|
|
• a sharp boundary between the neural plate and the rest of the ectoderm is absent
|
|
• lack postotic vagal level neural crest cells
|
|
• neural tube fails to close
|
|
• cranial neural crest cells do not delaminate nor do they initiate migration
|
|
• cranial neural crest cells do not delaminate at the junctional zone between the neural and surface ectoderm
|
|
• the first branchial arch is missing
|
|
• do not undergo embryonic turning
|
|
• embryos are severely retarded in growth by E9.5
|
|
• a sharp boundary between the neural plate and the rest of the ectoderm is absent
|
|
• lack postotic vagal level neural crest cells
|
|
• neural tube fails to close
|
|
• the first branchial arch is missing
|
|
• cranial neural crest cells do not delaminate nor do they initiate migration
|
|
• cranial neural crest cells do not delaminate at the junctional zone between the neural and surface ectoderm
|
Mouse Models of Human Disease |
DO ID | OMIM ID(s) | Ref(s) | |
| Mowat-Wilson syndrome | DOID:0060485 |
OMIM:235730 |
J:82084 | |
|
|
| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
|
• embryos die between E9.5 and E10.5
|
|
• embryos exhibit variety of defects at E8.5
|
|
|
| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
|
• defects in neural plate as shown by decreased Sox2 expression
|
|
• dorsal neural tube fails to close at E8.5
|
|
• somite cleavage stops at somite 7 while embryo elongation continues
(J:108819)
|
|
• at the 7-somite stage, somites are irregular in the shape of their boundary
|
|
• at the 7-somite stage, the somites are shorter in the rostro-caudal dimension, however the size of somites in the lateral dimension is normal
(J:101031)
|
|
• defects in neural plate as shown by decreased Sox2 expression
|
|
• dorsal neural tube fails to close at E8.5
|
|
|
| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
| N |
• do not develop aganglionic phenotypes phenotypes similar to patients with Mowat-Wilson Syndrome (Hirschsprung disease-mental retardation syndrome)
|
Mouse Models of Human Disease |
DO ID | OMIM ID(s) | Ref(s) | |
| NOT | Mowat-Wilson syndrome | DOID:0060485 |
OMIM:235730 |
J:82084 |
|
|
| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
|
• 14 of 16 exhibit maxillonasal clefts of varying severity, ranging from incomplete fusion of the maxillonasal processes to complete cleft of the processes
|
|
• the spinal cord is dorsally open in the tail region
|
|
• in the cerebrum, the shape of the ventricle is irregular, lined by a wavy ventricular zone
|
|
• 8 of 16 exhibit exencephaly accompanied by the cerebrum defects
|
|
• the spinal cord is dorsally open in the tail region
|
|
• 14 of 16 exhibit maxillonasal clefts of varying severity, ranging from incomplete fusion of the maxillonasal processes to complete cleft of the processes
|
|
|
| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
 |
• 70% exhibit closure of the vaginal orifice
|
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
||
|
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support. |
last database update 05/07/2024 MGI 6.23 |
|
|
|
||