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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Tcf3tm3Zhu
targeted mutation 3, Yuan Zhuang
MGI:2387352
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Tcf3tm3Zhu/Tcf3tm3Zhu involves: 129/Sv * C57BL/6 MGI:3776845
ht2
 		Tcf3tm1Wein/Tcf3tm3Zhu involves: 129/Sv * 129S4/SvJaeSor * C57BL/6 MGI:3776846


Genotype
MGI:3776845
hm1
Allelic
Composition		 Tcf3tm3Zhu/Tcf3tm3Zhu
Genetic
Background		 involves: 129/Sv * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tcf3tm3Zhu mutation (0 available); any Tcf3 mutation (48 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system
decreased B cell number ( J:47671 )
• mice contain 40% of wild-type B cell numbers

immune system
immune system phenotype ( J:47671 )
N
• B cell development is normal
decreased B cell number ( J:47671 )
• mice contain 40% of wild-type B cell numbers




Genotype
MGI:3776846
ht2
Allelic
Composition		 Tcf3tm1Wein/Tcf3tm3Zhu
Genetic
Background		 involves: 129/Sv * 129S4/SvJaeSor * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tcf3tm1Wein mutation (0 available); any Tcf3 mutation (48 available)
Tcf3tm3Zhu mutation (0 available); any Tcf3 mutation (48 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
postnatal lethality, incomplete penetrance ( J:47671 )
• postnatal survival is lower than normal but improved compared to Tcfe2a null mice

hematopoietic system

immune system




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
09/30/2025
MGI 6.24 		The Jackson Laboratory