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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Runx1tm2Dow
targeted mutation 2, James R Downing
MGI:2387300
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
ht1
 		Runx1tm2Dow/Runx1+ involves: 129P2/OlaHsd * C57BL/6 MGI:2667307


Genotype
MGI:2667307
ht1
Allelic
Composition		 Runx1tm2Dow/Runx1+
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Runx1tm2Dow mutation (0 available); any Runx1 mutation (34 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging

cardiovascular system
hemopericardium ( J:79160 )
• evident at E12.5
intraventricular hemorrhage ( J:79160 )
• evident at E12.5

hematopoietic system
abnormal embryonic hematopoiesis ( J:79160 )
• failure of embryonic hematopoiesis

liver/biliary system
pale liver ( J:79160 )
• evident at E12.5

nervous system
intraventricular hemorrhage ( J:79160 )
• evident at E12.5

homeostasis/metabolism
hemopericardium ( J:79160 )
• evident at E12.5

embryo
abnormal embryonic hematopoiesis ( J:79160 )
• failure of embryonic hematopoiesis




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
09/30/2025
MGI 6.24 		The Jackson Laboratory