Phenotypes associated with this allele

• Allele Symbol: Dab2^tm1.1Cpr
• Allele Name: targeted mutation 1.1, Jonathan A Cooper
• Allele ID: MGI:2387168
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Dab2^tm1.1Cpr/Dab2^tm1.1Cpr	involves: 129S4/SvJaeSor * C57BL/6	MGI:3510686
cn2	Dab2^tm1Cpr/Dab2^tm1.1Cpr Meox2^tm1(cre)Sor/Meox2^+	involves: 129S4/SvJaeSor * C57BL/6	MGI:3510687

Genotype
MGI:3510686

hm1

• Allelic Composition: Dab2^tm1.1Cpr/Dab2^tm1.1Cpr
• Genetic Background: involves: 129S4/SvJaeSor * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

embryonic lethality during organogenesis, complete penetrance ( J:75911 )

• death occurs between E5.5 and E9.5

embryo

abnormal inner cell mass apoptosis ( J:75911 )

• inner cell mass fails to expand

• increased apoptosis

abnormal gastrulation ( J:75911 )

• fail to elongate extra-embryonic portion of the egg cylinder

decreased embryo size ( J:75911 )

• embryos small at E6.5

abnormal embryonic epiblast morphology ( J:75911 )

• disorganized epiblast

abnormal extraembryonic tissue morphology ( J:75911 )

absent allantois ( J:75911 )

• at E7.5

absent amnion ( J:75911 )

• absent amnion at E7.5

absent chorion ( J:75911 )

• absent at E7.5

small proamniotic cavity ( J:75911 )

• small proamniotic cavity at E6.5

abnormal visceral yolk sac cavity morphology ( J:75911 )

• yolk sac cavity is very large

abnormal visceral endoderm morphology ( J:75911 )

• failure to thin the distal tip of the visceral endoderm

absent anterior visceral endoderm ( J:75911 )

• absence of anterior visceral endoderm markers

growth/size/body

decreased embryo size ( J:75911 )

• embryos small at E6.5

cellular

abnormal inner cell mass apoptosis ( J:75911 )

• inner cell mass fails to expand

• increased apoptosis

Genotype
MGI:3510687

cn2

• Allelic Composition: Dab2^tm1Cpr/Dab2^tm1.1Cpr; Meox2^tm1(cre)Sor/Meox2⁺
• Genetic Background: involves: 129S4/SvJaeSor * C57BL/6

homeostasis/metabolism

increased urine protein level ( J:75911 )

• Vitamin D binding protein and retinol binding protein found in the urine

renal/urinary system

increased urine protein level ( J:75911 )

• Vitamin D binding protein and retinol binding protein found in the urine

abnormal proximal convoluted tubule morphology ( J:75911 )

• reduced numbers of coated pits and endocytic vescicles near the apical membrane of the proximal tubules