Phenotypes associated with this allele

• Allele Symbol: Cebpa^tm4Nerl
• Allele Name: targeted mutation 4, Claus Nerlov
• Allele ID: MGI:2387095
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Cebpa^tm4Nerl/Cebpa^tm4Nerl	involves: 129P2/OlaHsd * C57BL/6	MGI:3809500

Genotype
MGI:3809500

hm1

• Allelic Composition: Cebpa^tm4Nerl/Cebpa^tm4Nerl
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

premature death ( J:72330 )

• fewer than expected mice are alive at 8 weeks of age

adipose tissue

decreased white adipose tissue amount ( J:72330 )

• mice have little to no white adipose tissue unlike in wild-type mice

abnormal gonadal fat pad morphology ( J:72330 )

• the gonadal fat pad is hypotrophic and adipocytes within it are smaller than normal

hematopoietic system

abnormal granulocyte morphology ( J:72330 )

• granulocytes are apoptotic

decreased granulocyte number ( J:72330 )

• in the bone marrow and peripheral blood

immune system

immune system phenotype ( J:72330 )

N • despite the defects in granulocytes, other hematopoietic lineages are normal

abnormal granulocyte morphology ( J:72330 )

• granulocytes are apoptotic

decreased granulocyte number ( J:72330 )

• in the bone marrow and peripheral blood