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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Ngfrtm1Gdc
targeted mutation 1, Georg Dechant
MGI:2386981
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Ngfrtm1Gdc/Ngfrtm1Gdc involves: 129X1/SvJ * C57BL/6 MGI:2450868


Genotype
MGI:2450868
hm1
Allelic
Composition
Ngfrtm1Gdc/Ngfrtm1Gdc
Genetic
Background
involves: 129X1/SvJ * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ngfrtm1Gdc mutation (0 available); any Ngfr mutation (30 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• 40% fewer homozygous progeny than expected by mendelian ratios

behavior/neurological
• impaired motility due to hind limb ataxia
• abnormal response when held by tail, upward stretching of posterior limbs
• abnormal waddling, "mud-walking"

cardiovascular system
• dorsal aorta and other large blood vessels were dilated at E11.5
• thin vessel walls
• blood vessel ruptures and concomitant blood cell leakage observed

growth/size/body

nervous system
• 54% decrease in sensory neurons in L5 DRG relative to wild-type 3-4 days after birth
• ~53% decrease in cross-sectional area of sciatic nerve relative to wild-type





Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
04/30/2024
MGI 6.23
The Jackson Laboratory