Analysis Tools
normal phenotype
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• Remained viable and healthy until at least 18 months of age with no obvious phenotype
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Allele Symbol Allele Name Allele ID |
Ogg1tm1Tld targeted mutation 1, Tomas Lindahl MGI:2386943 |
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| Summary |
4 genotypes
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• Remained viable and healthy until at least 18 months of age with no obvious phenotype
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• the 50% survival age is 10.3 months
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• 65.7% of mice develop tumors, predominantly lymphoma (37.1%), ovarian tumors (34.8%), and lung adenomas (31.4%)
• 75% of lung tumors have a G to T mutation in codon 12 of Kras2
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• 34.8% of mutants develop ovarian tumors after 12 months of age
• 4 of 5 ovarian tumors are bilateral
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• most ovarian tumors are hemangiomas which can result in lethal hemorrhaging
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• observe in 37.1% of mice, with extensive lymphoma burdens in most organs such as the lung, heart, liver, spleen, kidneys, and lymph nodes
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• 31.4% of mutants develop lung tumors after 12 months of age
• 78.6% of older mutants that live more than 12 months develop lung tumors
• lung tumors are solitary and white nodules with a 1-10 mm diameter
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• most lung tumors are adenomas, seen in 31.4% of mutants
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• 34.8% of mutants develop ovarian tumors after 12 months of age
• 4 of 5 ovarian tumors are bilateral
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• 34.8% of mutants develop ovarian tumors after 12 months of age
• 4 of 5 ovarian tumors are bilateral
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• 31.4% of mutants develop lung tumors after 12 months of age
• 78.6% of older mutants that live more than 12 months develop lung tumors
• lung tumors are solitary and white nodules with a 1-10 mm diameter
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• most lung tumors are adenomas, seen in 31.4% of mutants
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• the 50% survival age is 4.3 months and all mutants die within 10.3 months
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• 86.7% of mice develop tumors, predominantly lymphoma (76.7%) with some incidence of lung adenoma (10%)
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• observe in 10% of mice
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• observe in 76.7% of mice
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• observe in 10% of mice
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• the 50% survival age is around 10 months
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• 76.9% of mice develop tumors, including ovarian tumors (57.6%), lung adenomas (35.9%), lung adenocarcinoma (61.3%), lymphoma (26.9%)
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• in 57.6% of mice, with the earliest onset at 5 months of age
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• observe in 35.9% of mice
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• observe in 26.9% of mice
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• 61.3% of mutants develop lung adenocarcinomas after 10.6 months of age
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• observe in 35.9% of mice
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• 61.3% of mutants develop lung adenocarcinomas after 10.6 months of age
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• in 57.6% of mice, with the earliest onset at 5 months of age
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• in 57.6% of mice, with the earliest onset at 5 months of age
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 04/16/2024 MGI 6.23 |
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