Phenotypes associated with this allele

• Allele Symbol: Mesp2⁺
• Allele Name: wild type
• Allele ID: MGI:2386847
• Summary: 4 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
ht1	Mesp2^tm17.1(VP16/Rbpj)Ysa/Mesp2^+	involves: C57BL/6 * CBA	MGI:4867479
ht2	Mesp2^tm13(cre/Esr1*)Ysa/Mesp2^+	involves: C57BL/6J	MGI:5431509
ht3	Mesp2^tm13(cre/Esr1*)Ysa/Mesp2^+	Not Specified	MGI:5431508
cx4	Lfng^tm1Rjo/Lfng^tm1Rjo Mesp2^tm15.1(Lfng)Ysa/Mesp2^+	involves: 129S7/SvEvBrd	MGI:4454336

Genotype
MGI:4867479

ht1

• Allelic Composition: Mesp2^{tm17.1(VP16/Rbpj)Ysa}/Mesp2⁺
• Genetic Background: involves: C57BL/6 * CBA

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

skeleton

skeleton phenotype ( J:167045 )

N • despite expressing a constitutively active form of Rbpj, no abnormalities are detected

Genotype
MGI:5431509

ht2

• Allelic Composition: Mesp2^{tm13(cre/Esr1*)Ysa}/Mesp2⁺
• Genetic Background: involves: C57BL/6J

skeleton

abnormal vertebrae morphology ( J:186213 )

• following exposure to mild hypoxia, mice exhibit increased rate and severity of vertebrae defects compared with wild-type mice

Genotype
MGI:5431508

ht3

• Allelic Composition: Mesp2^{tm13(cre/Esr1*)Ysa}/Mesp2⁺
• Genetic Background: Not Specified

skeleton

abnormal vertebrae morphology ( J:186213 )

• in few mice at E14.5

Genotype
MGI:4454336

cx4

• Allelic Composition: Lfng^tm1Rjo/Lfng^tm1Rjo; Mesp2^{tm15.1(Lfng)Ysa}/Mesp2⁺
• Genetic Background: involves: 129S7/SvEvBrd

embryo

abnormal somite development ( J:159983 )

• the segmental morphology in the developing embryos is similar to that in Lfng^tm1Rjo single homozygotes

abnormal dorsal-ventral polarity of the somites ( J:159983 )

• abnormal vertebral morphology along the anteroposterior axis as is seen in Lfng^tm1Rjo single homozygotes