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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Mesp2tm4Ysa
targeted mutation 4, Yumiko Saga
MGI:2386844
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Mesp2tm4Ysa/Mesp2tm4Ysa involves: C57BL/6 * CBA MGI:2678614
cx2
 		Mesp2tm4Ysa/Mesp2tm4Ysa
Psen1tm1Shs/Psen1tm1Shs 		involves: C57BL/6 * CBA MGI:3715287


Genotype
MGI:2678614
hm1
Allelic
Composition		 Mesp2tm4Ysa/Mesp2tm4Ysa
Genetic
Background		 involves: C57BL/6 * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mesp2tm4Ysa mutation (1 available); any Mesp2 mutation (30 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
skeleton
abnormal vertebral lamina morphology ( J:78989 )
• at P17.5, lamina are fused
abnormal vertebral pedicle morphology ( J:78989 )
• at P17.5, pedicles are fused
abnormal vertebral transverse process morphology ( J:78989 )
• at P17.5, transverse processes are fused

embryo
abnormal somite development ( J:78989 )
• segmentation of somatic mesoderm is impaired




Genotype
MGI:3715287
cx2
Allelic
Composition		 Mesp2tm4Ysa/Mesp2tm4Ysa
Psen1tm1Shs/Psen1tm1Shs
Genetic
Background		 involves: C57BL/6 * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mesp2tm4Ysa mutation (1 available); any Mesp2 mutation (30 available)
Psen1tm1Shs mutation (0 available); any Psen1 mutation (61 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
skeleton
abnormal vertebral arch morphology ( J:78989 )
• mice have the same skeletal defects as Mesp2tm4Ysa homozygotes




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
09/30/2025
MGI 6.24 		The Jackson Laboratory