Phenotypes associated with this allele

• Allele Symbol: Hydin^{hy3-Tg(Bdnf)459Ove}
• Allele Name: transgene insertion 459, Paul Overbeek
• Allele ID: MGI:2386736
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Hydin^hy3-Tg(Bdnf)459Ove/Hydin^hy3-Tg(Bdnf)459Ove	FVB/N-Hydin^hy3-Tg(Bdnf)459Ove	MGI:3819150

Genotype
MGI:3819150

hm1

• Allelic Composition: Hydin^{hy3-Tg(Bdnf)459Ove}/Hydin^{hy3-Tg(Bdnf)459Ove}
• Genetic Background: FVB/N-Hydin^{hy3-Tg(Bdnf)459Ove}

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

Hydrocephalus in Hydin^{hy3-Tg(Bdnf)459Ove}/Hydin^{hy3-Tg(Bdnf)459Ove} mice

mortality/aging

postnatal lethality, complete penetrance ( J:80595 )

• mice die at 1 and 3 weeks after birth

nervous system

abnormal brain ependyma motile cilium morphology ( J:135322 )

• defective ependymal cilia bending

abnormal brain ependyma motile cilium physiology ( J:135322 )

• delayed switching between forward and backward motion, lower beat frequency, and impaired cilia-generated flow

hydrocephaly ( J:80595 , J:135322 )

• hydroencephaly is associated with defective ependymal cilia bending, delayed switching between forward and backward motion, lower beat frequency, and impaired cilia-generated flow (J:135322)

enlarged brain ventricles ( J:80595 )

• mice exhibit enlarged brain ventricles compared to in wild-type mice

growth/size/body

megacephaly ( J:80595 )

• mice that survive past day 10 exhibit an enlarged head

decreased body size ( J:80595 )

• mice exhibit a failure to thrive and are smaller than normal

respiratory system

abnormal respiratory motile cilium physiology ( J:135322 )

• mice exhibit impaired tracheal cilia bending, lower beat frequency, and cilia-generated flow compared to in wild-type mice

abnormal mucociliary clearance ( J:135322 )

• mice exhibit impaired tracheal cilia bending, lower beat frequency, and cilia-generated flow compared to in wild-type mice

cellular

abnormal brain ependyma motile cilium morphology ( J:135322 )

• defective ependymal cilia bending

abnormal brain ependyma motile cilium physiology ( J:135322 )

• delayed switching between forward and backward motion, lower beat frequency, and impaired cilia-generated flow

abnormal respiratory motile cilium physiology ( J:135322 )

• mice exhibit impaired tracheal cilia bending, lower beat frequency, and cilia-generated flow compared to in wild-type mice